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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Zusätzlich bieten wir Ihnen Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 Antikörper (104) und Potassium Inwardly-Rectifying Channel, Subfamily J, Member 3 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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these data suggest that patients with estrogen receptor (zeige ESR1 Proteine) positive breast cancer might be stratified into high risk and low risk groups based on the KCNJ3 levels in the tumor
Results clearly corroborate that overexpression of GIRK1 protein exerts profound effects on wound healing, chemoinvasion and cellular motility in the MCF-7 breast cancer cell line suggesting a role to promote invasion and metastasis.
GIRK1/GIRK4 (zeige KCNJ5 Proteine) hetero-tetramers are not activated by Na+, but rather are in a permanent state of high responsiveness to G proteins beta-gamma, suggesting that the GIRK1 subunit functions like a GIRK4 (zeige KCNJ5 Proteine) subunit with Na+ permanently bound.
The findings of this study suggest that variations in KCNJ3 genes are associated with both mild and severe persistent breast pain after breast cancer surgery.
For KCNJ3 rs7574878, individuals who were heterozygous or homozygous for the rare G allele (TT versus TG+ GG) had a 48% reduction in the odds of reporting preoperative breast pain.
we show that Kir3.1, in the absence of trafficking partner subunits, can exit the endoplasmic reticulum (ER) and reach the Golgi (though not the plasma membrane)
Conformational changes at the Gbetagamma/Kir3 interface were lost when Kir3.1 subunits were replaced.
These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the "channelopathy theory of psychiatric illnesses".
Kir3.1 channel is involved in the TLR4 (zeige TLR4 Proteine)-mediated signal at an early event by facilitating the recruitment of TLR4 (zeige TLR4 Proteine) into lipid raft.
halothane (zeige RYR1 Proteine) predominantly interferes with Gbetagamma-mediated Kir3 currents, such as those functioning during inhibitory synaptic activity
histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2 (zeige KCNJ2 Proteine), Kcnj3, Kcnj5 (zeige KCNJ5 Proteine), Kcnj11 (zeige KCNJ11 Proteine), and Kcnh2 (zeige KCNH2 Proteine))
Kir 3.1 channels are important for supraspinal antinociception and presynaptic GABA release inhibition by oxycodone in the femur bone cancer model
GABA neurons in the ventral tegmental area express GIRK1 (and GIRK2 (zeige KCNJ6 Proteine)) subunits.
siRNA knock-down of NgR1 (zeige NEUROG1 Proteine) resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1.
Discontinuous and sometime opposing elements in Girk1 underlie the Girk1-dependent potentiation of receptor-dependent and receptor-independent heteromeric channel activity.
Mechanism for functional dysregulation in the dorsal raphe follows tyrosine phosphorylation of repeated stress-activated Kir3.1 channels.
NMR analyses of the Gbetagamma binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (zeige KCNA5 Proteine) (GIRK1).
Agonist-induced localization of Gq-coupled receptors and G protein-gated inwardly rectifying K+ (GIRK) channels to caveolae determines receptor specificity of phosphatidylinositol 4,5-bisphosphate signaling
The atrial potassium channel (zeige KCNAB2 Proteine), I(KACH), ion channel gating is accelerated in atrial myocytes through the RGS6 (zeige RGS6 Proteine)/Gbeta5 (zeige GNB5 Proteine) complex.
Dopamine neurons from Girk1 knock-out mice (and Girk2 (zeige KCNJ6 Proteine)) exhibited elevated glutamatergic neurotransmission and increased synaptic levels of AMPA (zeige GRIA3 Proteine) glutamate (zeige GRIN1 Proteine) receptors.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.
G protein-activated inward rectifier potassium channel 1
, inward rectifier K(+) channel Kir3.1
, inward rectifier K+ channel KIR3.1
, potassium channel, inwardly rectifying subfamily J member 3
, potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e
, potassium inwardly-rectifying channel J3
, potassium channel inwarding rectifying channel subfamily J member 3
, potassium channel subunit Kir3.1 type 3 delta
, inward rectifying potassium channel, Kir3.1