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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Zusätzlich bieten wir Ihnen KCNJ2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 93 products:
Mammalian Monoclonal KCNJ2 Primary Antibody für ISt, IHC - ABIN1304735
DiFranco, Yu, Quiñonez, Vergara: Inward rectifier potassium currents in mammalian skeletal muscle fibres. in The Journal of physiology 2015
Show all 9 Pubmed References
Human Polyclonal KCNJ2 Primary Antibody für EIA, IHC (fro) - ABIN1107936
Hinard, Belin, Konig, Bader, Bernheim: Initiation of human myoblast differentiation via dephosphorylation of Kir2.1 K+ channels at tyrosine 242. in Development (Cambridge, England) 2008
Dog (Canine) Polyclonal KCNJ2 Primary Antibody für WB - ABIN2177159
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014
We report a novel KCNJ2 sequence variant (p.Y145C) in a family with diagnosed Andersen-Tawil syndrome.
Combined inhibition of IKr and IKur produced a synergistic anti-arrhythmic effect in both forms of SQT3. In conclusion, this study provides mechanistic insights into atrial proarrhythmia with SQT3 Kir2.1 mutations and highlights possible pharmacological strategies for management of SQT3-linked AF.
Data suggest that an R204A mutation disrupts the characteristic cytoplasmic domain subunit interface salt bridges in Kir2.1 reducing apparent sensitivity of channel activity to ligand PIP2 (phosphatidylinositol bisphosphate).
These findings suggest that KCNJ2 plays an important role in the pathophysiology of Thyrotoxic Periodic Paralysis in Korean Graves' Disease patients with Thyrotoxic Periodic Paralysis .
Nav1.5 (zeige SCN5A Antikörper) N-terminal domain binding to alpha1-syntrophin (zeige SNTA1 Antikörper) increases membrane density of human Kir2.1, Kir2.2 (zeige KCNJ12 Antikörper) and Nav1.5 (zeige SCN5A Antikörper) channels
Kir2.1 may participate in macrophage maturation and differentiation, and play a key role in lipid uptake and foam cell formation through modulating the expression of scavenger receptors.
a Korean family with Andersen-Tawil syndrome with a G215D mutation of the KCNJ2 gene revealed by diagnostic exome sequencing, is reported.
Chloroethylclonidine interact with Kir2.1 channels in the cytoplasmic pore.
Variability has been found in a three-generation family with Pierre Robin sequence, acampomelic campomelic dysplasia, and intellectual disability due to a novel approximately 1 Mb deletion upstream of SOX9 (zeige SOX9 Antikörper), and including KCNJ2 and KCNJ16 (zeige KCNJ16 Antikörper).
Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 (zeige KCNN3 Antikörper) and KCNJ2 Genes and CACNG8 (zeige CACNG8 Antikörper)-Linked Left Ventricular Dysfunction
Following differentiation with LPS (zeige TLR4 Antikörper) or a combination of LPS (zeige TLR4 Antikörper) and IFN-gamma (zeige IFNG Antikörper) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (zeige CSN3 Antikörper) 3.1 and Kir (zeige GEM Antikörper) currents, while microglia differentiated with IL-4 (zeige IL4 Antikörper) exhibited large Kir (zeige GEM Antikörper) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (zeige CSN3 Antikörper) 3.1 currents were generally low
Cellular electrophysiology assays of mouse Kir2.1 and human Kir2.2 indicated that, consistent with simulations, the Leu residue increased the channel responses to phosphatidylinositol diphosphate (PIP2) through increased binding affinity and faster activation kinetics, and the deactivation kinetics decreased upon PIP2 inhibition.
histone H4 (zeige HIST1H4H Antikörper) hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2, Kcnj3 (zeige KCNJ3 Antikörper), Kcnj5 (zeige KCNJ5 Antikörper), Kcnj11 (zeige KCNJ11 Antikörper), and Kcnh2 (zeige KCNH2 Antikörper))
Our results support the concept that endothelial cell Kir2 channels boost vasodilatory signals that are generated by Ca(2 (zeige CA2 Antikörper)+) -dependent activation of IK and SK channels.
Results suggest that a promyogenic cell adhesion molecule (zeige MCAM Antikörper) Cdo (zeige CDO1 Antikörper) signaling is critical for Inward rectifier potassium channel Kir2.1 activities in the induction of myogenic differentiation.
The data suggest that microglial Kir2.1 channels may represent novel therapeutic targets to inhibit excessive reactive oxygen species production by primed microglia in brain pathology.
Three pairs of weak interactions precisely regulate the G-loop gate of Kir2.1 channel.
Suggest that Kir2.1 channels, in part, account for hyperpolarization and associated absence of tone in urinary bladder arterioles.
This finding represents the first functional evidence for a significant role of the dystrophin (zeige DMD Antikörper)-associated protein complex in the regulation of Kir2.x channels.
Intracellular Mg(2 (zeige MCOLN1 Antikörper)+) and SPM (zeige NPC1 Antikörper) therefore may have a synergistic action on the pore-blocking effect, presumably via prohibition of the outward exit of the higher-affinity blocking SPM (zeige NPC1 Antikörper) by the lower-affinity Mg(2 (zeige MCOLN1 Antikörper)+).
Hypoxic stress up-regulates Kir2.1 expression and facilitates cell proliferation in brain capillary endothelial cells.
Kir2.1 may mediate native Kir (zeige GEM Antikörper) currents responsible for setting resting membrane potential in bovine parotid cells and might be, at least in part, involved in spontaneous secretion in ruminant parotid glands.
There were substantial transmural gradients in Cav1.2 (zeige CACNA1C Antikörper), KChIP2 (zeige KCNIP2 Antikörper), ERG (zeige KCNH2 Antikörper), KvLQT1 (zeige KCNQ1 Antikörper), Kir2.1, NCX1 (zeige SLC8A1 Antikörper), SERCA2a (zeige ATP2A2 Antikörper) and RyR2 (zeige RYR2 Antikörper) at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.
, inward rectifier K(+) channel Kir2.1
, inward rectifier potassium channel 2
, potassium channel, inwardly rectifying subfamily J member 2
, cardiac inward rectifier potassium channel
, inward rectifier K+ channel KIR2.1
, inward rectifier potassium channel cIRK1
, cardiac inward rectifier KIR2.1
, inwardly rectifying potassium channel Kir2.1
, inward rectifier potassium channel Kir2.1
, inwardly-rectifying potassium channel Kir2.1