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Outward rectifying potassium channel. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Mammalian Monoclonal KCNT2 Primary Antibody für ISt, IHC - ABIN1304959
Wojtovich, Sherman, Nadtochiy, Urciuoli, Brookes, Nehrke: SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. in PLoS ONE 2011
Show all 2 Pubmed References
In the present study, we evaluated two other potential mechanisms for stabilization of Slo2 (zeige KCNT1 Antikörper) channels in a closed state: (1) dewetting and collapse of the inner pore (hydrophobic gating) and (2) constriction of the inner pore by tight criss-crossing of the cytoplasmic ends of the S6 alpha-helical segments.
mRNA of aquaporin 1 (zeige AQP1 Antikörper) was co-expressed in Xenopus oocytes with homomeric or heteromeric Slick and Slack (zeige KCNT1 Antikörper) alpha-subunits. Hypotonic or hypertonic buffers caused changes in current. The heteromeric channel had a characteristic graded sensitivity to small and fast changes in cell volume. This the cell volume sensitivity is dependent on the number of volume sensitive Slick alpha-subunits in the tetrameric channels.
KCNT2 SNPs were associated with lifetime cannabis use, but the association did not reach genome-wide significance. [Meta-Analysis]
Together these results suggest that hydrophobic interactions between residues in S5 and the C-terminal end of the pore helix stabilize Slo2.1 channels in a closed state.
Charge reversal of Asp757 of Slo2.1 prevented activation of channels by intracellular Na+, whereas activation by niflumic acid was unaffected.
Slick channels, in contrast to the similar Slack (zeige KCNT1 Antikörper) channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume.
Together these findings suggest that (1) the selectivity filter and not the bundle crossing gates ion permeation and (2) dynamic coupling between the pore helix and the S5 and S6 segments mediates Slo2.1 channel activation.
Cloning and regulation of slick channel activity.
This study showed that the Intense Slick channel immunoreactivity was observed in processes, varicosities, and neuronal cell bodies of the olfactory bulb, granular zones of cortical regions, hippocampus, amygdala, lateral septal nuclei, certain hypothalamic and midbrain nuclei, and several regions of the brainstem.
Slick (Slo2.1 (zeige KCNT1 Antikörper)) is required for both volatile anesthetics-stimulated K flux and for the anesthetic preconditioning-induced cardioprotection
Slick and Slack (zeige KCNT1 Antikörper) are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation.
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.
potassium channel, subfamily T, member 2
, potassium channel subfamily T member 2-like
, potassium channel subfamily T member 2
, sequence like an intermediate conductance potassium channel subunit
, sodium activated potassium channel
, sodium and chloride activated ATP sensitive potassium channel
, sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
, sodium- and chloride-activated ATP-sensitive potassium channel
, sodium-and chloride-activated ATP-sensitive potassium channel (SLICK)
, sodium- and chloride-activated ATP-sensitive potassium channel subunit