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OLR1 encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. Zusätzlich bieten wir Ihnen OLR1 Antikörper (221) und OLR1 Kits (80) und viele weitere Produktgruppen zu diesem Protein an.
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ox-LDL and LOX-1 increase due to subarachnoid hemorrhage and they may play a role in the pathogenesis of vasospasm.
LOX (zeige LOX Proteine) and LOXL2 (zeige LOXL2 Proteine) play an important role in wound healing after glaucoma filtration surgery. Targeting LOXL2 (zeige LOXL2 Proteine) with an inhibitory monoclonal antibody (GS-607601) had a broader efficacy than targeting LOX (zeige LOX Proteine), reducing angiogenesis and inflammation, and fibrosis.
Angiotensin (1-7) inhibited LOX-1 expression and diminished Ang II (zeige AGT Proteine)-mediated inflammation in endothelial cells
Elevated LOX-1 expression and inflammatory responses are induced in hypercholesterolemic rabbits by Chlamydia pneumoniae GroEL1 heat shock protein.
Early treatment with fluvastatin had a crucial endothelial protective effect by down-regulating LOX-1 expression level in atherosclerotic arteries in early atherosclerosis.
LOX-1 expression appears to be closely associated with tissue factor (zeige F3 Proteine) expression, apoptotic events and morphological vulnerability in atherosclerotic lesions
High LOX1 expression is associated with colorectal cancer.
Increased LOX-1 expression in endothelial cells is potentially involved in the pathogenesis of sickle cell disease vasculopathy
LOX-1 signalling and the crucial role of cytokines
High OLR1 expression is associated with breast cancer.
Multiple classical molecular dynamics simulations have been applied to the human LOX-1 receptor to clarify the role of the Trp150Ala mutation in the loss of binding activity. Results indicate that the substitution of this crucial residue, located at the dimer interface, markedly disrupts the wild-type receptor dynamics
Carrying the C allele of the rs11053646 variant of the OLR1 gene was associated with an increased risk of CAD in heterozygous adult patients with FH, and this risk could be even greater in smokers as well as in younger patients.
Berberine could prevent the oxLDL and TNFalpha (zeige TNF Proteine) - induced LOX1 expression and oxidative stress, key events that lead to NOX, MAPK (zeige MAPK1 Proteine)/Erk1/2 and NF-kappaB (zeige NFKB1 Proteine) activation linked to endothelial dysfunction.
Data suggest Klotho (zeige KL Proteine) attenuates ox-LDL- (oxidized low density lipoprotein)-induced oxidative stress in vascular endothelial cells via up-regulation of oxidative scavengers (lipoprotein and nitric oxide), activation of the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/eNOS (zeige NOS3 Proteine) signaling, and down-regulation of LOX1 (lectin-like ox-LDL receptor (zeige LDLR Proteine)) expression. (PI3K (zeige PIK3CA Proteine) = phosphatidylinositol 3-Kinase; Akt (zeige AKT1 Proteine) = proto-oncogene c-Akt (zeige AKT1 Proteine); eNOS (zeige NOS3 Proteine) = endothelial nitric oxide synthase (zeige NOS3 Proteine))
Individuals >/=30 years old with abdominal obesity presented lower Lox1 levels than patients >/=30 years old without abdominal obesity.
These studies suggest that activation of LOX-1 expression occurs through binding of the chlamydial glycan and provides one mechanism by which Chlamydia pneumoniae infection could play a role in the pathogenesis of atherosclerosis.
At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway.
The findings suggested that ox-LDL could induce cardiac hypertrophy through the direct association of AT1-R (zeige AGTR1 Proteine) and LOX-1.
Adiponectin, TNF-alpha (zeige TNF Proteine), and LOX-1 exert complex regulatory effects on the coronary microvascular endothelial function in atherosclerotic ApoE (zeige APOE Proteine) knockout mice.
LOX-1 in cardiomyocytes plays an important role in the pathology of doxorubicin-induced cardiomyopathy. LOX-1 deletion altered the LOX-1-related signaling pathway, which led to improvements in cardiac function, myocardial inflammation, fibrosis and degenerative changes after DOX treatment.
Therefore we concluded that HNG (zeige NRGN Proteine) could inhibit ox-LDL-induced macrophage-derived foam cell formation, which occurs because of a decrease in lipid uptake and an increase in cholesterol efflux from macrophage cells.
The study indicated that the LOX-1/ox-LDL system in chondrocytes plays a role in the pathogenesis of age-related knee knee osteoarthritis, which is potentially a target for preventing knee osteoarthritis progression.
We demonstrated that varenicline upregulates expression of LOX-1 and CD36 (zeige CD36 Proteine) significantly through alpha7 nAChR (zeige CHRNA7 Proteine), thereby promoting oxLDL uptake in macrophages.
this study shows that LOX-1 can regulate inflammation through regulation of generation of reactive oxygen species in in Aspergillus fumigatus keratitis
The in vitro and in vivo models revealed that lipid metabolism disorder and FK506 caused oxidative stress and a fibrogenic response. In addition, decreased levels of LOX1 markedly reduced the levels of TGFb1 (zeige TGFB1 Proteine) in the in vitro model.
LOX-1/ox-LDL system plays a pivotal role in the pathogenesis of instability-induced osteoarthritis through endochondral ossification.
Endothelial LOX-1 overexpression in an atherosclerosis-prone LDL receptor (zeige LDLR Proteine) knockout mice impairs endothelial function, proving its importance in the development of atherosclerosis.
bta-miR (zeige MYLIP Proteine)-370 has a negative regulatory effect on the OLR1 gene at both the gene and protein expression levels and has a role in lipid metabolism in bovine adipocytes
Overexpression of LOX-1 leads to the attenuation of protective autophagy response in aortic endothelial cells.
These results imply that the 3' UTR SNP of the OLR1 gene is a strong candidate marker for selection in cattle breeding programs.
Our data indicate that blocking the LOX-1 receptor signal pathway might be a promising way to improve steroid hormone concentrations in metabolically highly active female mammals
In the present study, we show that inhibition of LOX-1 leads to a rearrangement of ceramide from the basal membrane toward the Golgi apparatus
The downregulation of eNOS (zeige NOS3 Proteine) by ox-low-density lipoprotein, as driven by LOX-1-mediated endoplasmic stress, is associated with the PI3K-Akt (zeige AKT1 Proteine)-eNOS (zeige NOS3 Proteine) signaling pathway.
3'-UTR SNP assoicated with milk composition traits and somatic cell score
Oxidized low-density lipoprotein receptor (zeige LDLR Proteine) (OLR1) single nucleotide polymorphism haplotype is associated with milk fat yield and fat percentage
synergistic effects of cyclic tensile stretch load and ox-LDL on cell viability and proteoglycan (zeige Vcan Proteine) synthesis in chondrocytes, which may be mediated through enhanced expression of LOX-1
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.
oxidised low density lipoprotein (lectin-like) receptor 1
, oxidized low density lipoprotein (lectin-like) receptor 1
, lectin-like oxLDL receptor 1
, lectin-like oxidized LDL receptor 1
, lectin-type oxidized LDL receptor 1
, ox-LDL receptor 1
, oxidized low-density lipoprotein receptor 1
, C-type lectin domain family 8 member A
, ox LDL receptor 1
, oxidized low-density lipoprotein receptor 1, soluble form
, scavenger receptor class E, member 1
, Lectin-like oxidized low-density lipoprotein receptor-1
, lectin-like oxidized low-density lipoprotein receptor
, lectin-like oxidized LDL receptor-1
, oxidized low density lipoprotein receptor 1