OLR1 Protein (AA 61-273) (His tag)

Produktnummer ABIN7275197

Produktdetails

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 61-273

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses OLR1 Protein ist gelabelt mit His tag.

Verwendungszweck: Human LOX1 Protein

Sequenz: Ser61-Gln273

Produktmerkmale: Recombinant Human LOX1 Protein is expressed from HEK293 with His tag at the N-Terminus.It contains Ser61-Gln273.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Andere Bezeichnung: LOX1 (OLR1 Produkte)

Synonyme: OLR1 Protein, LOX1 Protein, Olr1 Protein, CLEC8A Protein, LOXIN Protein, SCARE1 Protein, SLOX1 Protein, LOX-1 Protein, SR-EI Protein, Scare1 Protein, Oldlr1 Protein, Oldr1 Protein, PLOX-1 Protein, oxidized low density lipoprotein receptor 1 Protein, oxidized low density lipoprotein (lectin-like) receptor 1 Protein, OLR1 Protein, Olr1 Protein

Hintergrund: LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.

Molekulargewicht: 25.4 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on Tris-Bis PAGE result.