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OPCML encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. Zusätzlich bieten wir Ihnen Opioid Binding Protein/cell Adhesion Molecule-Like Antikörper (71) und Opioid Binding Protein/cell Adhesion Molecule-Like Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Here we show that, though OPCML interacts only with HER2 (zeige ERBB2 Proteine) and not with EGFR (zeige EGFR Proteine), the interaction of OPCML with HER2 (zeige ERBB2 Proteine) disrupts the formation of the HER2 (zeige ERBB2 Proteine)-EGFR (zeige EGFR Proteine) heterodimer, and this translates into a better response to both lapatinib and erlotinib in HER2 (zeige ERBB2 Proteine)-expressing ovarian and breast cancer cell lines
Study revealed that reduced expression of OPCML might have a significant correlation with unfavorable tumor stage and differentiation, predict poor prognosis of patients with gastric cancer. OPCML had a tumor-suppressing activity possibly via AKT/GSK3beta signaling in gastric cancer.
OPCML and FLRT2 (zeige FLRT2 Proteine) were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR (zeige WDR20 Proteine) loci
OPCML plays an important role in gastric cancer, and may be a new prognostic indicator of gastric cancer.
the DNA methylation (zeige HELLS Proteine) levels of OPCML and SFRP1 (zeige SFRP1 Proteine) could be potential biomarkers for diagnosis of CCA (zeige FBN2 Proteine) with high specificity, sensitivity, and accuracy, in particular for biopsy specimens
The generation and cardiac phenotype of single and double heterozygous gene-targeted OPCML and Neurotrimin (zeige NTM Proteine) knockout mice.
Detection of OPCML hypermethylation in the serum is useful for diagnosis of ovarian carcinoma.
The OPCML tumor suppressor negatively regulates a specific spectrum of receptor tyrosine kinases in ovarian cancer cells by binding to their extracellular domain.
A strong association was found between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population
opioid binding protein/cell adhesion molecule-like promoter methylation has a role in bladder carcinoma
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.
IgLON family member 1
, opioid binding protein/cell adhesion molecule-like preprotein
, opioid-binding protein/cell adhesion molecule
, opioid binding cell adhesion molecule
, opioid-binding cell adhesion molecule
, opioid-binding protein/cell adhesion molecule-like
, OBCAM alpha 1 isoform
, OBCAM protein gamma isoform
, neurite inhibitor GP55-A
, opioid-binding protein/cell adhesion molecule homolog