OPCML Protein (AA 5-313) (His tag)

Produktnummer ABIN7320058

Produktdetails

Target: OPCML (Opioid Binding Protein/cell Adhesion Molecule-Like (OPCML))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 5-313

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses OPCML Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse OBCAM/OPCML Protein (aa 5-313, His Tag)(Active)

Sequenz: Ala5-Val313

Produktmerkmale: A DNA sequence encoding the mouse OPCML (NP_808574.2) (Ala5-Val313) was expressed with a C-terminal polyhistidine tag.

Reinheit: > 95 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: 1. Measured by its binding ability in a functional ELISA.2. Immobilized mouse OPCmL-His at 10μg/mL (100μL/well) can bind human LSAMP-Fc .The EC50 of human LSAMP-Fc is 0.04-0.1 μg/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: OPCML (Opioid Binding Protein/cell Adhesion Molecule-Like (OPCML))

Andere Bezeichnung: OBCAM/OPCML (OPCML Produkte)

Synonyme: IGLON1 Protein, OBCAM Protein, OPCM Protein, 2900075O15Rik Protein, 3732419F12 Protein, AI844366 Protein, B930023M13Rik Protein, C230027C17 Protein, Gm181 Protein, Obcam Protein, opioid binding protein/cell adhesion molecule like Protein, opioid binding protein/cell adhesion molecule-like Protein, OPCML Protein, Opcml Protein

Hintergrund:

Background: Opioid-binding Cell Adhesion Molecule (OBCAM), also known as OPCML, is a GPI-anchored cell adhesion molecule in the plasma membrane. This neuron-specific protein, consists of three immunoglobulin (Ig)-like domains anchored to the membrane through a glycosylphosphatidylinositol (GPI)-tail. OPCML also belongs to the member of the IgLON family, a subgroup of the immunoglobulin superfamily, consisting of three members, LAMP, OBCAM, and Neurotrimin. These molecules interact homophilically and heterophilically within the family, and OBCAM acts only as heterodimers with LAMP or Neurotrimin and possibly inhibits neurite outgrowth from cerebellar granule cells. OBCAM has been presumed to play a role as a cell adhesion/recognition molecule. Furthermore, the OPCML protein defects may play an important role in the carcinogenesis of cervical or ovarian cancers, and this gene is regarded as a candidate TSG (tumor suppressor gene).

Synonym: 2900075O15Rik,3732419F12,AI844366,B930023M13Rik,C230027C17,Gm181,Obcam,B-CAM,Gplu,Lu

Molekulargewicht: 32.7 kDa

NCBI Accession: NP_808574