-
Data indicate zinc finger protein 64 (ZFP64) as an essential transcription factor in mixed-lineage leukemia protein (MLL)-rearranged leukemia.
-
identified a distinctive signature for patients with KMT2A (MLL) rearrangement, with high HDAC9 and MEF2D expression, regardless of age, KMT2A partner and lineage.
-
PHF20L1 associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by the MLL1/WDR5 complexes
-
Results show that MLL1 gene is down regulated by miR-193a in prostate cancer and its 3'-UTR mRNA region interacts with miR-193a.
-
We report a comparison of the specificities of the human MLL1 and TET3 CXXC domains bound to dsDNA containing either cytosine, 5mC, or an enzymatically oxidized 5mC derivatives, in CpG or non-CpG context. With respect to CXXC domain specificity towards non-modified DNA, our work extends a recent analysis, but accounts more carefully for possible confounding influences of cytosine bases away from the site of interest.
-
GNB2 transcripts were significantly upregulated in human MLL-AML compared to MLL-negative AML.
-
This study analyzed the molecular and transcriptional consequences of human KMT2A variants to further understand the contribution of KMT2A-dependent methylation to the etiology of intellectual disability and hypertrichosis in Wiedemann-Steiner syndrome.
-
Reciprocal MLL fusion may be functionally rescued by a partially truncated MLL protein in childhood acute leukemias
-
These results support the notion that the CXXC zinc finger domain of KMT2A gene is a hotspot for missense variants associated with more severe neurophenotypes.
-
MLL-partial tandem duplication was detected in 6-7% of patients with MDS that were screened by the array during the same time period
-
This system provides for rapid systematic screening of relative risk, dose dependence, and combinatorial impact of multitudes of dietary and environmental exposures on MLL-AF9 translocations
-
Acute myeloid leukemia patients with high initial MLL-partial tandem duplication levels have lower induction complete remission and survival rates.
-
The molecular characterization of MLL breakpoints suggests different etiologies in the different age groups.
-
A pivotal pathway for MLL-rearranged leukaemic maintenance.
-
our work shows that ALOX5 plays a moderate anti-tumor role and functions as a drug sensitizer, with a therapeutic potential, in MLL-rearranged AML.
-
Studied lysine methyltransferase 2A (KMT2A) genetic rearrangements in child and young adult T-lymphoblastic leukemia/lymphoma.
-
Our experience suggests that AML with KMT2A rearrangement should be considered for the differential diagnosis of infantile cases with atypical monocytosis suggestive of JMML. Cytogenetic studies, including fluorescence in situ hybridization analysis of KMT2A, may be helpful in distinguishing between AML with KMT2A rearrangement and JMML.
-
Replication stress-induced recruitment of EndoG to the MLLbcr.
-
Wiedemann-Steiner syndrome causative splice and missense variants lead to reduction of KMT2A function.
-
SETD2 is required to maintain high H3K79 di-methylation and MLL-AF9-binding to critical target genes, such as Hoxa9.