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Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
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Data report the solution structure of the Mob1 protein from Xenopus laevis solved by heteronuclear multidimensional NMR.
mats1 plays a critical role in regulating cell proliferation and apoptosis during early development in zebrafish[mats1]
validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 (zeige PTPN5 Proteine) and Mob1a.
Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A regulates its interaction with both MST (zeige MAP3K10 Proteine) kinases and LATS/NDR (zeige STK38 Proteine) family kinases in vitro.
In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases.
MOB1 (zeige MOBKL3 Proteine) binds differently to the NDR2 (zeige STK38L Proteine) and LATS1 kinases.MOB1 interaction with Hippo and MST (zeige MAP3K10 Proteine) protein is not essential for development and tissue growth control.
No relationship has been found between the MOBKL1B-NS5A interaction and hepatitis C virus replication.
The RING ligase praja2 ubiquitylates and degrades Mob, a core component of NDR/LATS kinase and a positive regulator of the tumour-suppressor Hippo cascade.
Mob1A and Mob1B (zeige MOB1B Proteine) are needed for cell abscission and centriole re-joining after telophase and cytokinesis.
Results suggest that Mob1 (zeige MOBKL3 Proteine) and the other mammalian orthologues of the mitotic exit network regulate mitotic progression by facilitating the timely mobilization of the chromosomal passenger complex to the spindle midzone.
hMOB1A and hMOB1B are 2 LATS-binding proteins that may function as tumor suppressors in human cancer cells.
Mats1 can rescue the lethality associated with loss of Mats function in Drosophila; As Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans
MOB1A and MOB1B (zeige MOB1B Proteine) have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway.
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).
MOB1, Mps One Binder kinase activator-like 1B
, Mob4B protein
, mps one binder kinase activator-like 1B
, MOB1, Mps One Binder kinase activator-like 1B (yeast)
, Mps one binder kinase activator-like 1B
, mob1 homolog 1B
, MOB1 Mps One Binder homolog A
, mob1 alpha