MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) Proteine (MOBKL1B)

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).

• MOB kinase activator 1A L homeolog (mob1a.L)
• MOB kinase activator 1A (MOB1A)
• MOB kinase activator 1A (mob1a)
• MOB kinase activator 1A pseudogene (LOC712156)
• MOB kinase activator 1A (Mob1a)

• 4022402H07Rik Protein
• C2orf6 Protein
• MATS1 Protein
• MOB1 Protein
• MOB1A Protein
• Alle Synonyme
• MOB4B Protein
• Mobk1b Protein
• Mobkl1b Protein
• wu:fv69d04 Protein
• zgc:56189 Protein

MOB1, Mps One Binder kinase activator-like 1B , Mob4B protein , mps one binder kinase activator-like 1B , MOB1, Mps One Binder kinase activator-like 1B (yeast) , mats1 , mobk1b , Mps one binder kinase activator-like 1B , mob1 homolog 1B , MOB1 Mps One Binder homolog A , mob1 alpha