MOB1A Protein (AA 2-216) (His-SUMO Tag)

Produktnummer ABIN5711829

Produktdetails

Target: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Protein-Typ: Recombinant

Proteineigenschaft: AA 2-216

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses MOB1A Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: SFLFSSRSSK TFKPKKNIPE GSHQYELLKH AEATLGSGNL RQAVMLPEGE DLNEWIAVNT VDFFNQINML YGTITEFCTE ASCPVMSAGP RYEYHWADGT NIKKPIKCSA PKYIDYLMTW VQDQLDDETL FPSKIGVPFP KNFMSVAKTI LKRLFRVYAH IYHQHFDSVM QLQEEAHLNT SFKHFIFFVQ EFNLIDRREL APLQELIEKL GSKDR

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Andere Bezeichnung: MOB1A (MOBKL1B Produkte)

Synonyme: mob1 Protein, mob4b Protein, MOB1A Protein, MOBK1B Protein, MOB1 Protein, mats1 Protein, mobk1b Protein, mobkl1b Protein, MOBKL1B Protein, wu:fv69d04 Protein, zgc:56189 Protein, C2orf6 Protein, MATS1 Protein, Mob4B Protein, 4022402H07Rik Protein, MOB4B Protein, Mobk1b Protein, Mobkl1b Protein, MOB kinase activator 1A L homeolog Protein, MOB kinase activator 1A Protein, MOB kinase activator 1A pseudogene Protein, mob1a.L Protein, MOB1A Protein, mob1a Protein, LOC712156 Protein, Mob1a Protein

Hintergrund: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Molekulargewicht: 40.9 kDa

UniProt: Q9H8S9