anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) Antikörper

The protein encoded by LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. Zusätzlich bieten wir Ihnen LDLRAP1 Kits (9) und LDLRAP1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
LDLRAP1 26119 Q5SW96
LDLRAP1 100017 Q8C142
LDLRAP1 500564  
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Top anti-LDLRAP1 Antikörper auf antikoerper-online.de

Showing 10 out of 128 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-LDLRAP1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit Target Name: Ldlrap1 Sample Type: Mouse Testis lysates Antibody Dilution: 1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert ELISA, WB ABIN185037 staining (3µg/ml) of Human Liver lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Maus Unkonjugiert FACS, IHC (p), WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of LDLRAP1 Antibody (N-term) (ABIN392553) in K562 cell line lysates (35 µg/lane). LDLRAP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with LDLRAP1 antibody (N-term) (ABIN392553), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert FACS, IF, IHC (p), WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$522.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of LDLRAP1 Antibody (C-term) (ABIN392554) in NCI-H460 cell line lysates (35 µg/lane). LDLRAP1 (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with LDLRAP1 antibody (C-term)(ABIN392554), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p) 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Rind (Kuh) Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details

LDLRAP1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , , ,
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Rat (Rattus)
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Am meisten referenzierte anti-LDLRAP1 Antikörper

  1. Human Monoclonal LDLRAP1 Primary Antibody für IF, IHC (p) - ABIN565226 : Quagliarini, Vallvé, Campagna, Alvaro, Fuentes-Jimenez, Sirinian, Meloni, Masana, Arca: Autosomal recessive hypercholesterolemia in Spanish kindred due to a large deletion in the ARH gene. in Molecular genetics and metabolism 2007 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal LDLRAP1 Primary Antibody für ELISA, WB - ABIN249957 : He, Gupta, Yi, Michaely, Hobbs, Cohen: ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal LDLRAP1 Primary Antibody für WB - ABIN631410 : Holla, Strøm, Cameron, Berge, Leren: A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9. in Molecular genetics and metabolism 2010 (PubMed)

Weitere Antikörper gegen LDLRAP1 Interaktionspartner

Human Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) Interaktionspartner

  1. LDLRAP1 associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age /=160 mg/dl.

  2. Numb (zeige NUMB Antikörper) specifically regulates NPC1L1 (zeige NPC1L1 Antikörper)-mediated cholesterol absorption both in human intestine and liver, distinct from ARH and Dab2 (zeige DAB2 Antikörper), which selectively participate in LDLR (zeige LDLR Antikörper)-mediated LDL uptake.

  3. Identification of ARH gene and characterization of its mutations in Autosomal Recessive Hypercholesterolemia patients [Review]

  4. cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.

  5. This work identified a combined LDL receptor (zeige LDLR Antikörper) and LDLRAP1 mutation as the cause for severe familial hypercholesterolemia in a family of Turkish descent.

  6. The report provides evidence that endocytosis of the ROMK potassium channel is controlled by LDLRAP1 (ARH). ROMK binds directly to the LDLRAP1, and this interaction is mediated by a novel variant of the canonical "NPXY" endocytotic signal, YxNPxFV. LDLRAP1-knockout mice are unable to physiologically regulate ROMK.

  7. report the crystal structure at 1.37-A resolution of the phosphotyrosine-binding (PTB (zeige PTBP1 Antikörper)) domain of ARH in complex with an LDLR (zeige LDLR Antikörper) tail peptide containing the FxNPxY(0) internalization signal

  8. LDL receptor (zeige LDLR Antikörper)/LDLRAP1 double heterozygous mutations may account for severer phenotype in terms of xanthoma and atherosclerotic cardiovascular disease in familial hypercholesterolemia patients.

  9. ARH protein is involved in cell cycle progression, possibly by affecting nuclear membrane formation through interaction with lamin B1 (zeige LMNB1 Antikörper) or other mitotic proteins, and its absence affects cell proliferation and induces premature senescence.

  10. Knockdown of ARH in polarized epithelial cells leads to specific apical missorting of truncated LDLR (zeige LDLR Antikörper), which encodes only the FxNPxY motif (LDLR (zeige LDLR Antikörper)-CT27 (zeige CTCFL Antikörper)).

Mouse (Murine) Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) Interaktionspartner

  1. The combination of Arh and Dab2 (zeige DAB2 Antikörper) is responsible for the majority of adaptor function in LDLR (zeige LDLR Antikörper) endocytosis and LDLR (zeige LDLR Antikörper)-mediated cholesterol homeostasis.

  2. cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.

  3. results are consistent with LDL receptor adaptor protein(ARH) playing a critical and specific role in low density lipoprotein receptor (zeige LDLR Antikörper) endocytosis in the liver

  4. Hepatocytes do not take-up LDL in vivo without ARH protein, but they normally catabolize LDL in vitro. Thus, the requirement of ARH protein for proper functioning of the LDLR (zeige LDLR Antikörper) is not cell-specific, but rather may depend on the cellular environment.

  5. the LDL receptor (zeige LDLR Antikörper) alone can account for the clearance of apoE (zeige APOE Antikörper)-containing lipoproteins in mice, and the contribution of other receptors is minimal, and b) defects in either increase the sensitivity to apoE (zeige APOE Antikörper)-induced hypertriglyceridemia in mice.

  6. Taken together, our data suggest that ARH is a multifunctional protein whose spectrum of function in the brain goes beyond the traditionally known metabolism of lipoproteins, and that ARH may be locally synthesized in the axon.

  7. the endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis

  8. Loss of gamma-secretase function decreased endocytosis of low-density lipoprotein (LDL) receptor (zeige LDLR Antikörper)

  9. ARH marks ROMK for clathrin-dependent endocytosis, in concert with the demands of potassium homeostasis

LDLRAP1 Antigen-Profil

Protein Überblick

The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.

Genbezeichner und Symbole assoziert mit LDLRAP1

  • low density lipoprotein receptor adaptor protein 1 (ldlrap1) Antikörper
  • low density lipoprotein receptor adaptor protein 1 (LDLRAP1) Antikörper
  • low density lipoprotein receptor adaptor protein 1 (Ldlrap1) Antikörper
  • low density lipoprotein receptor adaptor protein 1 S homeolog (ldlrap1.S) Antikörper
  • low density lipoprotein receptor adaptor protein 1 L homeolog (ldlrap1.L) Antikörper
  • low density lipoprotein receptor adaptor protein 1a (ldlrap1a) Antikörper
  • AA691260 Antikörper
  • Arh Antikörper
  • Arh1 Antikörper
  • ARH2 Antikörper
  • FHCB1 Antikörper
  • FHCB2 Antikörper
  • ldlrap1 Antikörper
  • RGD1563417 Antikörper
  • sb:cb50 Antikörper
  • xptb Antikörper
  • zgc:56121 Antikörper

Bezeichner auf Proteinebene für LDLRAP1

low density lipoprotein receptor adaptor protein 1 , low-density lipoprotein adaptor protein , low density lipoprotein receptor adapter protein 1 , LDL receptor adaptor protein , autosomal recessive hypercholesterolemia protein , autosomal recessive hypercholesterolemia protein homolog , ARH beta , autosomal recessive hypercholesterolemia protein homolog beta , low density lipoprotein receptor adapter protein 1-B , xARH beta , ARH alpha , autosomal recessive hypercholesterolemia protein homolog alpha , low density lipoprotein receptor adapter protein 1-A , phosphotyrosine binding protein , phosphotyrosine-binding protein , xARH alpha , xcat4

GENE ID SPEZIES
549868 Xenopus (Silurana) tropicalis
739347 Pan troglodytes
100125967 Sus scrofa
100342213 Oryctolagus cuniculus
511199 Bos taurus
26119 Homo sapiens
612219 Canis lupus familiaris
100017 Mus musculus
500564 Rattus norvegicus
414519 Xenopus laevis
419589 Gallus gallus
398568 Xenopus laevis
368278 Danio rerio
Ausgewählte Anbieter für anti-LDLRAP1 (LDLRAP1) Antikörper
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