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In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells.
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Kif18B is only modestly processive and that the motor switches frequently between directed and diffusive modes of motility.
High KIF18B expression is associated with neoplasms.
Kif18B is a new microtubule dynamics regulatory protein that interacts with EB1 (zeige MAPRE2 Antikörper) to control astral microtubule length
Results uncover a novel role for Aurora A (zeige AURKA Antikörper)/B kinases in regulating spindle MT dynamics through Kif18b-MCAK (zeige KIF2C Antikörper) and suggest that the Kif18b-MCAK (zeige KIF2C Antikörper) complex constitutes the major MT plus-end depolymerizing activity in mitotic cells.
the expression of KIF18B is regulated in a cell cycle-dependent manner and therefore may play an important role(s) in cell division.
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity).
kinesin-like protein KIF18B
, N-8 kinesin