ISG15 Ubiquitin-Like Modifier Proteine (ISG15)

The protein encoded by ISG15 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Zusätzlich bieten wir Ihnen ISG15 Antikörper (148) und ISG15 Kits (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ISG15 9636 P05161
ISG15 100038882 Q64339
Ratte ISG15 ISG15 298693  
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Top ISG15 Proteine auf antikoerper-online.de

Showing 10 out of 29 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,744.22
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,744.22
Details
Escherichia coli (E. coli) Human GST tag ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-157), (full length) protein (GST tag) 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$242.00
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Escherichia coli (E. coli) Human Unkonjugiert 1 mg Anmelden zum Anzeigen 20 bis 21 Tage
$206.80
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Escherichia coli (E. coli) Human CaM 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$242.00
Details
Escherichia coli (E. coli) Maus GST tag   50 μg Anmelden zum Anzeigen 11 Days
$341.00
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$154.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$125.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$860.20
Details

ISG15 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , , , , , , , , ,
Mouse (Murine)
, ,

Weitere Proteine zu ISG15 Ubiquitin-Like Modifier (ISG15) Interaktionspartnern

Human ISG15 Ubiquitin-Like Modifier (ISG15) Interaktionspartner

  1. findings revealed that MERS-CoV PLpro chiefly engages human ISG15 through its C-terminal domain; structure of MERS-CoV PLpro was solved to 2.4 A in complex with the C-terminal domain of hISG15; structure of MERS-CoV PLpro in complex with this domain exposed the interface between these two entities

  2. Our study demonstrates a protumor role of ISG15, and suggests that ISG15 is a prognostic predictor and a potential therapeutic target for nasopharyngeal carcinoma

  3. Results show that HERC5 mediates covalent ISG15 conjugation to parkin in mammalian cells and that ISG15 is conjugated to the Lys349 and Lys369 residues of parkin which increases its ubiquitin E3 ligase activity.

  4. Extracellular ISG15 signals cytokine secretion through the LFA-1 (zeige ITGAL Proteine) integrin receptor (CD11a (zeige ITGAL Proteine)/CD18 (zeige ITGB2 Proteine)) in natural killer cells.

  5. Results suggest that unconjugated ISG15 affects the functions of HCV NS5A through protein-protein interaction.

  6. This report demonstrates that ISG15 induced by Hepatitis E virus replication in Huh7-S10 (zeige L1CAM Proteine)-3 human liver cells plays an immunomodulatory role by negatively regulating type I Interferon (zeige IFNA Proteine) signaling and, thus, Hepatitis E virus sensitivity to type I Interferon (zeige IFNA Proteine).

  7. epletion of either ISG15 or UBE2L6/UBCH8 (zeige UBE2L6 Proteine) resulted in enhanced endogenous autophagic flux.

  8. unlike ISG15, ubiquitin and FAT10 (zeige UBD Proteine) are conjugated to a similar degree to newly translated and pre-existing proteins.

  9. This paper shows that ISG15 directly regulates Human Cytomegalovirus replication and that its accumulation restricts productive virus growth.

  10. The results suggest that integrin-adhesion-induced MRTF-A-SRF activation and ISG15 expression constitute a newly discovered signaling circuit that promotes cell migration and invasion.

Cow (Bovine) ISG15 Ubiquitin-Like Modifier (ISG15) Interaktionspartner

  1. ISG 15 gene expression is upregulated during 16-18 days of pregnancy and could be used as an early pregnancy marker in dairy cows, especially in heifers.

  2. ISG15, UBE1l (zeige UBA7 Proteine) and UBCH8 (zeige UBE2E2 Proteine) genes are significantly upregulated in the artificially inseminated pregnant cows.

  3. Data indicate that the expression profiles of ISG15, MX1 (zeige MX1 Proteine), MX2 (zeige MX2 Proteine), and OAS1 (zeige OAS1 Proteine) could be a useful diagnostic biomarker of gestation.

  4. ISG15 is an antiviral and inducible protein in bovine immunodeficiency virus infected bovin lung cells.

  5. ISG15 and conjugated proteins were expressed in corpus luteum of both cyclic and pregnant cows regardless of pregnancy status and were upregulated during early pregnancy

  6. interferon-stimulated protein (zeige ISG20 Proteine)(ISG15) was localized throughout the endometrium on day 18-23 of bovine pregnancy and was specifically localized to organelles and compartments of endometrial epithelial cells and stromal cells

  7. rbovISG15 is unstable over time in storage & dialysis. In vivo, conjugation of ISG15 to targeted proteins occurs inside the cell.

Zebrafish ISG15 Ubiquitin-Like Modifier (ISG15) Interaktionspartner

  1. Overall, these data demonstrate the antiviral effect of a fish ISG15 protein, revealing the conservation among vertebrates of an ISGylation mechanism likely directed against viruses.

Pig (Porcine) ISG15 Ubiquitin-Like Modifier (ISG15) Interaktionspartner

  1. NSP2 (zeige RTN2 Proteine) of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of ISG15.

  2. Results report identification and cloning of the ISG15 and ISG43 (zeige USP18 Proteine) genes in pig.

Mouse (Murine) ISG15 Ubiquitin-Like Modifier (ISG15) Interaktionspartner

  1. Extracellular ISG15 signals cytokine secretion through the LFA-1 (zeige ITGAL Proteine) integrin receptor (CD11a (zeige ITGAL Proteine)/CD18 (zeige ITGB2 Proteine)) in natural killer cells.

  2. results demonstrate that ISG15 governs the dynamic functionality of mitochondria, specifically, OXPHOS and mitophagy, broadening its physiological role as an antiviral agent.

  3. Loss of ISG15 expression and type I IFN signaling have transient effects on bacterial burden during M. tuberculosis infection in mice

  4. ISG15 acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis.

  5. USP18 (zeige USP18 Proteine)'s ISG15 specificity is mediated by a small interaction interface.

  6. Posttranslational protein modification by ISG15 plays an important role in antiviral defense

  7. These studies provide evidence, ISG15 is elevated following TBI in mice, preceding MLCK elevation, development of BBB disruption, and cerebral edema.

  8. Kruppel-like factor 9 (KLF9 (zeige KLF9 Proteine)) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.

  9. Propose that Isg15-dependent degradation of p53 (zeige TP53 Proteine) represents an alternative mechanism of controlling p53 (zeige TP53 Proteine) protein levels, and, thus, it is an attractive pathway for drug discovery.

  10. Embryo mortality occurs in pregnant Isg15(-/-) mice, is exacerbated by environmental insults like maternal hypoxia, and might result from impaired early decidualization, vascular development, and formation of the labyrinth.

Horse (Equine) ISG15 Ubiquitin-Like Modifier (ISG15) Interaktionspartner

  1. The expression of interferon-stimulated protein 15 kDa (ISG15) during pregnancy is described.[ISG15]

ISG15 Protein Überblick

Protein Überblick

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.

Genbezeichner und Symbole assoziert mit ISG15

  • ISG15 ubiquitin-like modifier (ISG15)
  • ISG15 ubiquitin-like modifier (isg15)
  • ISG15 ubiquitin-like modifier (Isg15)
  • G1p2 Protein
  • hUCRP Protein
  • IFI15 Protein
  • IGI15 Protein
  • IP17 Protein
  • Irfp Protein
  • ISG15 Protein
  • ISG17 Protein
  • ISG17/UCRP Protein
  • si:rp71-1c23.2 Protein
  • UCRP Protein

Bezeichner auf Proteinebene für ISG15

interferon, alpha-inducible protein (clone IFI-15K) , interferon-induced 17-kDa/15-kDa protein , interferon-stimulated protein, 15 kDa , ubiquitin cross-reactive protein , ubiquitin-like protein ISG15 , boUCRP , interferon-stimulated gene product 17 , ISG15 ubiquitin-like modifier , si:rp71-1c23.2 , zfISG15 , interferon stimulated gene, 15 kDa , interferon, alpha-inducible protein , interferon-induced 17 kDa protein , interferon-stimulated protein 15 , interferon-induced 15 kDa protein , interferon-induced 15-KDa protein , interferon-stimulated protein (15 kDa) , interferon stimulated gene 17 , interferon-stimulated protein 17/ubiquitin cross-reactive protein

GENE ID SPEZIES
9636 Homo sapiens
281871 Bos taurus
465390 Pan troglodytes
558956 Danio rerio
700141 Macaca mulatta
100145895 Sus scrofa
100174787 Felis catus
100038882 Mus musculus
298693 Rattus norvegicus
100855667 Canis lupus familiaris
100354504 Oryctolagus cuniculus
443057 Ovis aries
102169982 Capra hircus
100066364 Equus caballus
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