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ISG15 Protein (AA 2-157, full length) (GST tag)

ISG15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 90 % ELISA
Produktnummer ABIN1047868
  • Target Alle ISG15 Proteine anzeigen
    ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 2-157, full length
    Spezies
    • 10
    • 4
    • 2
    Human
    Quelle
    • 11
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses ISG15 Protein ist gelabelt mit GST tag.
    Applikation
    ELISA
    Sequenz
    GWDLTVKMLA GNEFQVSLSS SMSVSELKAQ ITQKIGVHAF QQRLAVHPSG VALQDRVPLA SQGLGPGSTV LLVVDKCDEP LSILVRNNKG RSSTYEVRLT QTVAHLKQQV SGLEGVQDDL FWLTFEGKPL EDQLPLGEYG LKPLSTVFMN LRLRGG
    Produktmerkmale
    Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
    Reinheit
    90 %
    Top Product
    Discover our top product ISG15 Protein
  • Kommentare

    The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Konzentration
    0.2-2 mg/mL
    Buffer
    Tris-based buffer, 50 % glycerol
    Handhabung
    Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
  • Knight, Fahey, Cordova, Hillman, Kutny, Reich, Blomstrom: "A 15-kDa interferon-induced protein is derived by COOH-terminal processing of a 17-kDa precursor." in: The Journal of biological chemistry, Vol. 263, Issue 10, pp. 4520-2, (1988) (PubMed).

    Reich, Evans, Levy, Fahey, Knight, Darnell: "Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 18, pp. 6394-8, (1987) (PubMed).

    Blomstrom, Fahey, Kutny, Korant, Knight: "Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence." in: The Journal of biological chemistry, Vol. 261, Issue 19, pp. 8811-6, (1986) (PubMed).

  • Target
    ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
    Andere Bezeichnung
    Ubiquitin-like protein ISG15 protein (ISG15 Produkte)
    Synonyme
    G1P2 Protein, IFI15 Protein, IP17 Protein, UCRP Protein, hUCRP Protein, ISG15 Protein, g1p2 Protein, si:rp71-1c23.2 Protein, G1p2 Protein, IGI15 Protein, Irfp Protein, ISG17 Protein, ISG17/UCRP Protein, ISG15 ubiquitin-like modifier Protein, ISG15 Protein, isg15 Protein, Isg15 Protein
    Hintergrund
    Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21 In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy By similarity. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21
    Molekulargewicht
    44.4 kD
    UniProt
    Q64339
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