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Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes.
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results define a network of E2F (zeige E2F1 Antikörper) target genes as susceptible to the regulatory influence of H1.2, where H1.2 augments global association of pRb (zeige RB1 Antikörper) with chromatin, enhances transcriptional repression by pRb (zeige RB1 Antikörper), and facilitates pRb (zeige RB1 Antikörper)-dependent cell-cycle arrest
BRG1 (zeige SMARCA4 Antikörper) participates in gene repression by interacting with H1.2, facilitating its deposition and stabilizing nucleosome positioning around the transcription start site.
Results show that histones H1.2 and H1.4 were observed in MDA-MB-231 metastatic breast cancer cells. The phosphorylation at S173 of histone H1.2 and S172, S187, T18, T146, and T154 of H1.4 significantly increases during M phase suggesting that these events are cell cycle-dependent. Also, the study reports the observation of the H1.2 SNP variant A18V in MCF-10A cells.
Histone H1.2-T165 post translational modifications are dispensable for chromatin binding and cell proliferation while the H1.4-K26 (zeige KRT26 Antikörper) modifications are essential for proper cell cycle progression.
H1.2 interacts with Cul4A (zeige CUL4A Antikörper) and PAF1 (zeige PEX2 Antikörper) to activate developmental regulatory genes.
H1.2 is less abundant than other histone H1 (zeige H1F0 Antikörper) variants at the transcription start sites of inactive genes, and promoters enriched in H1.2 are different from those enriched in other histone H1 (zeige H1F0 Antikörper) variants and tend to be repressed.
Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.
These data suggest that p53 (zeige TP53 Antikörper) acetylation-H1.2 phosphorylation cascade serves as a unique mechanism for triggering p53 (zeige TP53 Antikörper)-dependent DNA damage response pathways.
confirmed N-terminal acetylation on all isoforms plus a single internal acetylation site; phosphorylation sites were located on peptides containing the cyclin dependent kinase (zeige CDK1 Antikörper) (CDK (zeige CDK4 Antikörper)) consensus motif
The binding of histone H1 (zeige H1F0 Antikörper) to a general amyloid-like motif indicates that histone H1 (zeige H1F0 Antikörper) may play an important common role in diseases associated with amyloid-like fibrils.
Histone H1c gene expression is developmentally up-regulated to promote facultative heterochromatin in mature rod photoreceptors.
These results integrate the localization of an understudied type of chromatin proteins, namely the H1 variants, into the epigenome map of mouse ESCs (zeige NR2E3 Antikörper).
The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 (zeige H1F0 Antikörper) and H1c.
The amount of the linker histone H1c is strongly reduced in nuclear extracts of SCA7 (zeige ATXN7 Antikörper) retinas and that the cellular distribution of H1c is particularly altered in the facultative heterochromatin compartment.
The modular pattern of DNA methylation (zeige HELLS Antikörper) in the Ig heavy chain locus and histone modifications appears to be determined by at least 2 factors: the B-cell-specific transcription factor Pax5 (zeige PAX5 Antikörper) and linker histone H1 (zeige H1F0 Antikörper).
These observations reveal a mode of p53 (zeige TP53 Antikörper) regulation mediated by CHD8 (zeige CHD8 Antikörper), which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 (zeige TP53 Antikörper) function through recruitment of histone H1 (zeige H1F0 Antikörper).
H1 isoforms H1.0, H1.1, and H1.2 are non-responsive to hormone whereas prolonged dexamethasone treatment effectively dephosphorylated the H1.3, H1.4, and H1.5 isoforms
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
H1 histone family, member 2
, histone 1, H1c
, histone H1.2
, histone H1c
, histone H1d
, histone H1s-1
, H1 VAR.1
, histone H1
, histone H1.1
, histone cluster 1, H1c