anti-Histocompatibility (Minor) 13 (HM13) Antikörper

The protein encoded by HM13, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. Zusätzlich bieten wir Ihnen Histocompatibility (Minor) 13 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HM13 81502 Q8TCT9
HM13 14950 Q9D8V0
HM13    
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Top anti-Histocompatibility (Minor) 13 Antikörper auf antikoerper-online.de

Showing 10 out of 45 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB HM13 Antibody (C-term) (ABIN658313) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the HM13 antibody detected the HM13 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Huhn Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Maus Kaninchen Unkonjugiert WB Western Blot: Signal Peptide Peptidase Antibody [NBP1-74111] - Mouse Spleen Lysate 1ug/ml Gel Concentration 12% 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Antigen: 0.2ug/100ul, Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000, Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000, TMB staining, Read the data in MicroplateReader by 450nm 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details
Human Kaninchen Unkonjugiert ELISA, WB   200 μL Anmelden zum Anzeigen 7 bis 9 Tage
$793.83
Details
Human Kaninchen Unkonjugiert ICC, IF Immunocytochemistry/Immunofluorescence: Signal Peptide Peptidase Antibody  - Staining of human cell line U-2 OS shows localization to endoplasmic reticulum. 100 μL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry-Paraffin: Signal Peptide Peptidase Antibody [NBP1-92389] Staining of human pancreas shows strong cytoplasmic positivity in exocrine cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert IP, WB Western Blot: Signal Peptide Peptidase Antibody [NBP2-32276] - Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-SPP antibody NBP2-32276 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. Immunoprecipitation: Signal Peptide Peptidase Antibody [NBP2-32276] - Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN buffer from HeLa cells. Antibodies: Affinity purified rabbit anti-SPP antibody NBP2-32276 used for IP at 6 ug per reaction. SPP was also immunoprecipitated by rabbit anti-SPP antibody BL16569. For blotting immunoprecipitated SPP, NBP2-32276 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Kaninchen Unkonjugiert ELISA, WB   200 μL Anmelden zum Anzeigen 11 bis 16 Tage
$594.00
Details

HM13 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine) ,


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Weitere Antikörper gegen Histocompatibility (Minor) 13 Interaktionspartner

Human Histocompatibility (Minor) 13 (HM13) Interaktionspartner

  1. Though far from complete, our knowledge on pathophysiological functions of SPP/SPPL proteases, in particular based on studies in mice, has been significantly increased over the last years. Based on this, inhibition of distinct SPP/SPPL proteases has been proposed as a novel therapeutic concept e.g. for the treatment of autoimmunity and viral or protozoal infections, as we will discuss in this review.

  2. The domains involved in HO-1 (zeige HMOX1 Antikörper) translocation have been identified, and it was shown that SPP-mediated HO-1 (zeige HMOX1 Antikörper) cleavage is isoform-specific (HO-1 (zeige HMOX1 Antikörper) vs HO-2 (zeige HMOX2 Antikörper)) and independent of heme oxygenase (zeige HMOX1 Antikörper) activity.

  3. This study identifies that SPP affects EGFRvIII secretion profiles and thus promotes tumor progression, providing further understanding of the formation of secreted vesicles and driving role of EGFRvIII in Glioblastoma.

  4. structure of human SPP [SPP]

  5. identified human signal peptide peptidase as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases [SPP]

  6. identification and molecular cloning; expression analysis of the hIMP1 gene (located on chromosome 20) was performed in human cell tissues and transfected cell cultures [IMP1 (zeige IMPA1 Antikörper)]

  7. widespread expression of SPP in many tissues

  8. signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

  9. IMP1 (zeige IMPA1 Antikörper) is a bi-aspartic polytopic protease capable of cleaving transmembrane proteins such as presenilin 2 (zeige PSEN2 Antikörper).

  10. The peptide structure corresponding to the C-terminal residues from H13 ribosomal protein was determined using magnetic resonance spectroscopy.

Mouse (Murine) Histocompatibility (Minor) 13 (HM13) Interaktionspartner

  1. silencing of SPP and its family member SPPL2a led to a general reduction of surface peptide-MHC-I complexes, underlining the involvement of these enzymes in Ag processing and presentation.

  2. structural analysis of H13 peptides lacking MHC binding anchor motifs determines self-nonself discrimination

  3. widespread expression of SPP in many tissues; a distinct pattern of expression in the mature murine brain and during development indicates that SPP plays an important role in the establishment and maintenance of the nervous system

  4. A single minor histocompatibility antigen mismatch at the polymorphic H13 allele plays a role in chronic allograft rejection of solid organs such as obliterative airway disease development following murine tracheal transplantation.

  5. new splice variant,signal peptide peptidase (SPP)beta, with an additional in-frame exon inserted between exons 11 and 12 of SPPalpha

  6. Results show that two genetic systems show that alleles lacking methylation generate truncated H13 transcripts that undergo internal polyadenylation.

Histocompatibility (Minor) 13 (HM13) Antigen-Profil

Protein Überblick

The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit HM13

  • histocompatibility (minor) 13 (hm13) Antikörper
  • histocompatibility (minor) 13 L homeolog (hm13.L) Antikörper
  • minor histocompatibility antigen H13 (LOC469911) Antikörper
  • histocompatibility minor 13 (HM13) Antikörper
  • histocompatibility 13 (H13) Antikörper
  • 1200006O09Rik Antikörper
  • 4930443L17Rik Antikörper
  • 5031424B04Rik Antikörper
  • AV020344 Antikörper
  • cb228 Antikörper
  • dJ324O17.1 Antikörper
  • H-13 Antikörper
  • h13 Antikörper
  • Hm13 Antikörper
  • IMP1 Antikörper
  • IMPAS Antikörper
  • IMPAS-1 Antikörper
  • MGC68919 Antikörper
  • MSTP086 Antikörper
  • PSENL3 Antikörper
  • PSL3 Antikörper
  • Spp Antikörper
  • SPPL1 Antikörper
  • wu:fc11a06 Antikörper
  • zgc:56660 Antikörper
  • zgc:86862 Antikörper

Bezeichner auf Proteinebene für HM13

histocompatibility 13 , signal peptide peptidase , intramembrane aspartyl protease , histocompatibility (minor) 13 , minor histocompatibility antigen 13 , minor histocompatibility antigen H13 , minor histocompatibility antigen H13-like , IMP-1 , hIMP1 , intramembrane protease 1 , presenilin-like protein 3 , signal peptide peptidase beta , signal peptide peptidase like 1 , presenilin-like aspartyl protease

GENE ID SPEZIES
259190 Danio rerio
380568 Xenopus laevis
469911 Pan troglodytes
512534 Bos taurus
608355 Canis lupus familiaris
713216 Macaca mulatta
100010776 Monodelphis domestica
100053502 Equus caballus
100124822 Xenopus (Silurana) tropicalis
100348554 Oryctolagus cuniculus
100386877 Callithrix jacchus
100447672 Pongo abelii
100582871 Nomascus leucogenys
81502 Homo sapiens
14950 Mus musculus
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