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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Zusätzlich bieten wir Ihnen Histone H3.3 Kits (7) und Histone H3.3 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Downregulation of the H3.3 histone chaperone HIRA (zeige HIRA Antikörper) similarly impairs late gastrulation.
DLP (zeige DMD Antikörper) and ASF1 (zeige SRSF1 Antikörper) are part of a predeposition complex, which is recruited by XNP (zeige ATRX Antikörper) and is necessary to prevent DNA exposure in the nucleus.
FACT and PBAP complexes are recruited to chromatin boundaries in a GAGA factor-dependent manner, and are needed for H3.3 replacement to execute boundary functions.
describe a mechanism of chromatin regulation whereby the variant H3.3 is deposited at particular loci, including active rDNA arrays
Histone H3.3 gene may be required to provide postmeiotic histone H3.3 in the male germ line in transition to chromatin packaging in sperm.
Deposition and inheritance of actively modified H3.3 in regulatory regions maintains transcriptionally active chromatin.
H3F3A is the most frequently mutated giant cell tumor of bone driver gene. H3F3A mutations are not present in atypical giant cell tumor of bone.
H3F3A mutational testing may be a useful adjunct to differentiate giant cell tumor of bone from giant cell-rich sarcoma.
Report H3F3A/B mutations in cell tumors of bone, chondroblastomas, and aneurysmal bone cysts.
We determined the incidence of H3.3 G34 mutations in primary malignant bone tumors as assessed by genotype and H3.3 G34W immunostaining
The kinase activity of Aurora B (zeige AURKB Antikörper) on serine 31 of histone H3.3 was biochemically confirmed with nucleosomal substrates in vitro.
This study showed that heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (zeige HIST1H3D Antikörper) (n = 3) across all primary, contiguous, and metastatic tumor sites in all Diffuse intrinsic pontine glioma.
Study examined the relationship of K27M mutations in the distinct histone H3 (zeige HIST3H3 Antikörper) variants (i.e. HIST1H3B (zeige HIST1H3D Antikörper) and H3F3A) with specific pontine glioma biology
study found spinal high-grade gliomas in children and adults frequently harbor H3F3A (K27M) mutations
H3F3A and H3F3B mutation analysis appears to be a highly specific, although less sensitive, diagnostic tool for the distinction of GCTB and chondroblastoma from other giant cell-containing tumors.
we describe three interesting cases of paediatric glial and glioneuronal tumours harbouring both BRAF (zeige BRAF Antikörper) V600E and H3F3A K27M mutations.
results point to the importance of integrating histone modifications and MyoD (zeige MYOD1 Antikörper) chromatin binding for coordinated gene activation and repression during myogenic differentiation.
Data show that circulating histone H3 (zeige HIST3H3 Antikörper) increased significantly in necrotizing pancreatitis.
In H3f3a and H3f3b null mouse embryonic stem cells, H3.3 deficiency results in reduced levels of H3K9me3 level, H4K20me3 and ATRX (zeige ATRX Antikörper) at the telomeres, accompanied with an increase in telomeric transcription.
an important function of H3.3 is to support chromosomal heterochromatic structures, thus maintaining genome integrity during mammalian development.
Data indicate a function of the histone H3S28 phosphorylation mark in the activation of mammalian genes in response to MAP kinase (zeige MAPK1 Antikörper) pathway activation.
Data indicate that increased tumor necrosis factor (Tnfa (zeige TNF Antikörper)) and monocyte chemotactic protein 1 (Mcp1 (zeige CCL2 Antikörper); also known as Ccl2 (zeige CCL2 Antikörper)) expression in fatty liver at the chromatin level corresponds to changes in the level of histone H3 (zeige HIST3H3 Antikörper) acetylation.
An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.
Histone H3.3 regulates dynamic chromatin states during spermatogenesis.
H3.3 is a crucial maternal factor (zeige ZAR1 Antikörper) for oocyte reprogramming
Data demonstrate the importance of H3.3 in maintaining a chromatin landscape in embryonic stem cells that is important for proper gene regulation during differentiation.
Data suggest the combination of three genes RPL32 (zeige RPL32 Antikörper), RPS18 (zeige RPS18 Antikörper), and H3F3A is the most suitable for accurate normalization.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.
H3 histone, family 3A
, H3 histone, family 3B (H3.3B)
, H3L-like histone
, histone H3.3
, histone H3.3 variant
, histone H3.3A
, histone variant 3.3
, histone variant H3.3