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Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription.
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expression of histone macroH2A1.1 (zeige H2AFY Antikörper) and macroH2A2 predicts lung cancer recurrence.
Our results reveal unanticipated dynamic behavior of the MacroH2A2 variant in pluripotent cells, and provide a resource for future studies of tissue-specific histone dynamics in vivo.
Data show that MacroH2A (zeige H2AFY Antikörper).1 and macroH2A (zeige H2AFY Antikörper).2 regulate gene expression with them acting synergistically on the expression of some genes and apparently having opposing effects on others.
macroH2A1 (zeige H2AFY Antikörper) and macroH2A2, together with histone 3 lysine 27 methylated 3, co-occupy pluripotency genes in wild-type (wt) fibroblasts.
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
core histone macro-H2A.2
, core histone macroH2A2.2
, histone macroH2A2
, H2A histone family, member Y2
, H2A histone family, member Y-like