Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 Proteine (GADD45GIP1)

GADD45GIP1 encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. Zusätzlich bieten wir Ihnen Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 Antikörper (36) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GADD45GIP1 90480 Q8TAE8
GADD45GIP1 102060 Q9CR59
Ratte GADD45GIP1 GADD45GIP1 288916 Q5XJW2
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Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
$492.31
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,553.83
Details
Hefe REACT_Green monkey His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,553.83
Details

GADD45GIP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1) Interaktionspartnern

Human Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1) Interaktionspartner

  1. NRF2 (zeige GABPA Proteine) Ser40 phosphorylation was inhibited in Crif1-deficient bone marrow multipotent mesenchymal stromal cells even in the presence of three kinds of PKC (zeige PRRT2 Proteine) agonists, suggesting that CRIF1 might co-activate PKC-delta (zeige PKCd Proteine) to phosphorylate NRF2 (zeige GABPA Proteine) Ser40.

  2. strongly suggest that CRIF1 deficiency promotes endothelial cell inflammation by increasing VCAM-1 (zeige VCAM1 Proteine) expression, elevating inflammatory cytokines levels, and activating the transcription factor NF-kappaB (zeige NFKB1 Proteine), all of which were inhibited by SIRT1 (zeige SIRT1 Proteine) overexpression

  3. Results demonstrate that knockdown of CRIF1 in HUVECs induces mitochondrial dysfunction and reduces SIRT1 (zeige SIRT1 Proteine) expression along with decreased eNOS (zeige NOS3 Proteine) phosphorylation and increased eNOS (zeige NOS3 Proteine) acetylation, thereby promoting endothelial dysfunction. These findings indicate that CRIF1 plays an important role in maintaining mitochondrial and endothelial function through its effects on the SIRT1 (zeige SIRT1 Proteine)-eNOS (zeige NOS3 Proteine) pathway.

  4. SNF5 (zeige SMARCB1 Proteine) is indispensable for CRIF1-enhanced p53 (zeige TP53 Proteine) activity and its function in the suppression of cell cycle arrest in human cancer cells.

  5. Study shows that Lck (zeige LCK Proteine) interacts with CRIF1 in the mitochondria and negatively regulates CRIF1-mediated translation of mitochondrion-encoded proteins.

  6. our results support a novel function of nuclear Lck (zeige LCK Proteine) in promoting human leukemic T cell survival through interaction with a tumor suppressor, CRIF1

  7. Crif1 is an indispensable regulator of PKAalpha cat that modulates the PKA/CREB (zeige CREB1 Proteine) signaling pathway to promote adipogenic differentiation of bone marrow mesenchymal stem cells after irradiation

  8. The results identify the ROS (zeige ROS1 Proteine)-Sp1 (zeige PSG1 Proteine)-Crif1 pathway to be a new mechanism underlying Abeta (zeige APP Proteine)-induced mitochondrial dysfunction and suggest that ROS (zeige ROS1 Proteine)-mediated downregulation of Crif1 is a crucial event in AD pathology.

  9. CRIF1 knockdown partially induces endothelial activation via increased ROS (zeige ROS1 Proteine) production and phosphorylation of p66shc (zeige SHC1 Proteine)

  10. CRIF1 may play a regulatory role in the BM microenvironment-induced leukemia cell cycle arrest possibly through interacting with CDK2 (zeige CDK2 Proteine) and acting as a cyclin-dependent kinase (zeige CDK1 Proteine) inhibitor.

Mouse (Murine) Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1) Interaktionspartner

  1. Crif1(beta-/-) mouse is a useful model for the study of beta cell failure caused by mitochondrial OxPhos dysfunction.

  2. The results identify the ROS (zeige ROS1 Proteine)-Sp1 (zeige SP1 Proteine)-Crif1 pathway to be a new mechanism underlying Abeta (zeige APP Proteine)-induced mitochondrial dysfunction and suggest that ROS (zeige ROS1 Proteine)-mediated downregulation of Crif1 is a crucial event in AD pathology.

  3. CRIF1 knockdown partially induces endothelial activation via increased ROS (zeige ROS1 Proteine) production and phosphorylation of p66shc (zeige SHC1 Proteine)

  4. Study showed that loss of Crif1 impairs mitochondrial oxidative phosphorylation and adipocyte differentiation in vitro and in vivo.

  5. Crif1 plays a critical role in the maintenance of both mitochondrial structure and respiration in cardiac muscles.

  6. Although adipose-specific Crif1-haploinsufficient mice showed normal growth and development, they became insulin (zeige INS Proteine)-resistant.

  7. CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane.

  8. Results reveal that Crif1 is a novel and essential transcriptional coactivator of Elf3 (zeige EFNB3 Proteine) for the terminal differentiation of absorptive enterocytes.

  9. Crif1 is a novel and essential transcriptional coactivator of STAT3 (zeige STAT3 Proteine) that modulates its DNA binding ability.

Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1) Protein Überblick

Protein Überblick

This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators.

Genbezeichner und Symbole assoziert mit GADD45GIP1

  • growth arrest and DNA-damage-inducible, gamma interacting protein 1 (gadd45gip1)
  • GADD45G interacting protein 1 (GADD45GIP1)
  • growth arrest and DNA-damage-inducible, gamma interacting protein 1 (Gadd45gip1)
  • GADD45G interacting protein 1 (Gadd45gip1)
  • 2310040G17Rik Protein
  • AI425883 Protein
  • CKBBP2 Protein
  • Crif1 Protein
  • PLINP Protein
  • PLINP-1 Protein
  • Plinp1 Protein
  • PRG6 Protein
  • si:dkey-194e13.6 Protein

Bezeichner auf Proteinebene für GADD45GIP1

CKII beta binding protein 2 , CKII beta-associating protein , CR6 interacting factor 1 , growth arrest and DNA damage-inducible proteins-interacting protein 1 , growth arrest- and DNA damage-inducible GADD45G-interacting protein , p53-responsive gene 6 protein , papillomavirus L2 interacting nuclear protein 1 , growth arrest and DNA-damage-inducible proteins-interacting protein 1

GENE ID SPEZIES
402803 Danio rerio
90480 Homo sapiens
102060 Mus musculus
288916 Rattus norvegicus
504718 Bos taurus
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