Glyoxalase I Proteine (GLO1)

The enzyme encoded by GLO1 is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Zusätzlich bieten wir Ihnen Glyoxalase I Antikörper (152) und Glyoxalase I Kits (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GLO1 2739 Q04760
GLO1 109801 Q9CPU0
GLO1 294320 Q6P7Q4
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Showing 10 out of 28 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$270.00
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Baculovirus infected Insect Cells Maus His tag 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$492.31
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Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$717.00
Details
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$437.80
Details
Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$282.13
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$331.20
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
Details
Hefe Shigella flexneri His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,284.33
Details

GLO1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu Glyoxalase I (GLO1) Interaktionspartnern

Human Glyoxalase I (GLO1) Interaktionspartner

  1. This study shows that only the GLO1 C-7T polymorphism, and not the GLO1 A419C and ALR (zeige GFER Proteine) C-106T polymorphisms, is associated with carotid atherosclerosis in Chinese patients with type 2 diabetes.

  2. The expression of glyoxalase system member glyoxalase 1 (GLO1) in melanoma cells is downregulated by miR (zeige MLXIP Proteine)-137. siRNA targeting of GLO1 mimicks inhibition of melanoma cell proliferation caused by miR (zeige MLXIP Proteine)-137 overexpression. Re-expression of GLO1 restores miR (zeige MLXIP Proteine)-137-mediated suppression of melanoma cell proliferation.

  3. The critical role of glyoxalases as regulators of tumorigenesis in the prostate through modulation of various critical signaling pathways, and an overview of the current knowledge on glyoxalases in bladder, kidney and testis cancers is reviewed.(GLO1, GLO2 (zeige HAGH Proteine))

  4. Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE (zeige AGER Proteine) Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models

  5. current research highlighted the Glo-I/AGE/RAGE (zeige AGER Proteine) system as an interesting therapeutic target in chronic liver diseases. These findings need further elucidation in preclinical and clinical studies.

  6. GLO1-knockdown provoked collagen expression, endothelial inflammation and dysfunction and apoptosis which might contribute to vascular damage

  7. Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.

  8. Induced Glyoxalase 1 expression is a common feature in the pathogenesis of oropharyngeal squamous cell carcinoma

  9. The lowering of glycative stress via modulation of RAGE (zeige AGER Proteine)-AGE axis or glyoxalase 1 activity is beneficial for tubular homeostasis and the subsequent prevention and treatment of kidney disease, suggesting the possibility of novel therapeutic approaches which target glycative stress.

  10. Glo-1 responds to dicarbonyl stress to enhance cytoprotection at the transcriptional level through stress-responsive increase of Glo-1 expression.

Mouse (Murine) Glyoxalase I (GLO1) Interaktionspartner

  1. Transgenic mice overexpressing Glo1 on both FVB/NJ (FVB) or C57BL/6J (B6) backgrounds showed increased voluntary EtOH consumption compared to their wild-type littermates. Transgenic Glo1 knockdown mice on a B6 background showed decreased voluntary EtOH consumption. Genetic manipulations of Glo1 had no effect on sucrose, saccharin or water consumption.

  2. the Glo1-methylglyoxal pathway integrates maternal and neural precursor cell metabolism to regulate neural development.

  3. These data indicate that Glo1 knockout reduces anxiety-like behavior, but increases depression-like behavior.

  4. Alternative detoxification of methylglyoxal in GLO1(-/-) is achieved by increased catalytic efficiency of aldose reductase (zeige AKR1B1 Proteine) toward hemithioacetal (product of glutathione and methylglyoxal ), which is most likely caused by S-nitrosylation of aldose reductase (zeige AKR1B1 Proteine).

  5. Glo1 knockdown does not have major short term effects on the energy expenditure or the formation of atherosclerotic plaques.

  6. Crystal structure of the mouse Glo1-inhibitor complex was determined at 2.3 A resolution.

  7. Study demonstrates that GLO1 is a novel metabolic oncogene (zeige RAB1A Proteine) of the 6p21 amplicon, which promotes tumor growth and aberrant transcriptional signals via regulating cellular metabolic activities for energy production.

  8. the balance between methylglyoxal and age-dependent GLO1 downregulation contributes to delayed wound healing in old mice

  9. The difference in glyoxalase-1 mRNA was observed with Fkbp5 (zeige FKBP5 Proteine)-/- mice expressing 2-fold more glyoxylase-1 protein.

  10. pharmacological inhibition of GLO1 reduced anxiety, suggesting that GLO1 is a possible target for the treatment of anxiety disorders.

Arabidopsis thaliana Glyoxalase I (GLO1) Interaktionspartner

Glyoxalase I (GLO1) Protein Überblick

Protein Überblick

The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.

Genbezeichner und Symbole assoziert mit Glyoxalase I Proteine (GLO1)

  • glyoxalase I (GLO1)
  • glyoxalase 1 (Glo1)
  • glyoxalase 1 (glo1)
  • glyoxalase 1 L homeolog (glo1.L)
  • glyoxalase 1 S homeolog (glo1.S)
  • lactoylglutathione lyase (GST3)
  • glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein (GLX1)
  • lactoylglutathione lyase (STY1687)
  • lactoylglutathione lyase (GLO1)
  • glyoxalase I (Bcen_2094)
  • glyoxalase I (gloA)
  • glyoxalase I (Glo1)
  • 0610009E22Rik Protein
  • 1110008E19Rik Protein
  • 2510049H23Rik Protein
  • ATGLX1 Protein
  • AW550643 Protein
  • cb554 Protein
  • F12F1.32 Protein
  • F12F1_32 Protein
  • Glo-1 Protein
  • Glo-1r Protein
  • Glo-1s Protein
  • GLO1 Protein
  • Glo1-r Protein
  • Glo1-s Protein
  • glod1 Protein
  • GLY1 Protein
  • glyi Protein
  • GLYOXALASE I Protein
  • glyoxalase I homolog Protein
  • Qglo Protein
  • trypanothione-dependent glyoxalase I Protein
  • wu:fb82g09 Protein
  • zgc:66035 Protein

Bezeichner auf Proteinebene für Glyoxalase I Proteine (GLO1)

S-D-lactoylglutathione methylglyoxal lyase , aldoketomutase , glx I , glyoxalase domain containing 1 , ketone-aldehyde mutase , lactoyl glutathione lyase , lactoylglutathione lyase , methylglyoxalase , glyoxalase 1 complex , glyoxalase 1 regulatory , glyoxalase 1 structural , glyoxalase I , hypothetical protein , trypanothione-dependent glyoxalase I , glyoxylase 1

GENE ID SPEZIES
2739 Homo sapiens
109801 Mus musculus
368213 Danio rerio
421428 Gallus gallus
446359 Xenopus laevis
447401 Xenopus laevis
474894 Canis lupus familiaris
540335 Bos taurus
547925 Glycine max
594942 Xenopus (Silurana) tropicalis
719518 Macaca mulatta
748215 Pan troglodytes
837731 Arabidopsis thaliana
1248061 Salmonella enterica subsp. enterica serovar Typhi str. CT18
3639312 Candida albicans SC5314
4091104 Burkholderia cenocepacia AU 1054
4850985 Scheffersomyces stipitis CBS 6054
5073200 Leishmania infantum JPCM5
6924240 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91
6949741 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109
100156085 Sus scrofa
294320 Rattus norvegicus
100726491 Cavia porcellus
Ausgewählte Anbieter für Glyoxalase I Proteine (GLO1)
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