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GMEB1 encodes a member of KDWK gene family which associates with GMEB2 protein. Zusätzlich bieten wir Ihnen GMEB1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Bat Polyclonal GMEB1 Primary Antibody für WB - ABIN6746074
Hinton, Henderson, Blanks, Rudnicka, Miller: Monoclonal antibodies react with neuronal subpopulations in the human nervous system. in The Journal of comparative neurology 1988
Show all 2 Pubmed References
consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters
1.55 A resolution crystal structure of a central portion of GMEB1, encompassing its SAND domain
GMEB1 is capable of binding to the prodomain of caspase-2; findings indicated that GMEB1 might be an endogenous inhibitory protein that selectively interacts with prodomain of caspase-2 to disrupt the autoactivation
GMEB1 is an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis
GMEB1 effectively attenuated caspase activation and apoptosis caused by these stresses in human neuroblastoma SK-N-MC cells, indicating that it functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress.
Gmeb1 knockdown in midbrain dopamine (mDA) neurons resulted in downregulation of tyrosine hydroxylase and dopamine transporter, as well as in severe motor deficits. This study thus identifies Gmeb1 as a master regulator of mDA gene expression and function.
This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.
glucocorticoid modulatory element binding protein 1
, glucocorticoid modulatory element-binding protein 1-like
, DNA-binding protein p96PIF
, PIF p96
, glucocorticoid modulatory element-binding protein 1
, parvovirus initiation factor p96