GMEB1 Antikörper (AA 301-400) (Biotin)

Produktnummer ABIN1700878

Produktdetails anti-GMEB1 Antikörper (Biotin)

Target: GMEB1 (Glucocorticoid Modulatory Element Binding Protein 1 (GMEB1))

Bindungsspezifität: AA 301-400

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GMEB1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Cow,Sheep,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GMEB1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu GMEB1

Target: GMEB1 (Glucocorticoid Modulatory Element Binding Protein 1 (GMEB1))

Andere Bezeichnung: GMEB1 (GMEB1 Produkte)

Synonyme: MGC81052 antikoerper, GMEB1 antikoerper, si:ch211-245h7.5 antikoerper, pif96 antikoerper, p96pif antikoerper, MGC147529 antikoerper, P96PIF antikoerper, PIF96 antikoerper, 1110050A04Rik antikoerper, AI256615 antikoerper, AI481278 antikoerper, RGD1563208 antikoerper, glucocorticoid modulatory element binding protein 1 S homeolog antikoerper, glucocorticoid modulatory element binding protein 1 antikoerper, gmeb1.S antikoerper, GMEB1 antikoerper, gmeb1 antikoerper, Gmeb1 antikoerper

Hintergrund:

Synonyms: DNA binding protein p96P, DNA-binding protein p96P, Glucocorticoid modulatory element binding protein 1, Glucocorticoid modulatory element-binding protein 1, GMEB 1, GMEB-1, Gmeb1, GMEB1_HUMAN, P96P, Parvovirus initiation factor p96, P 96, P p96, P96.

Background: GMEB-1 is a 573 amino acid protein that contains one SAND domain and is a member of the KDWK family of combinatorial transcription modulators. Localized to both the cytoplasm and the nucleus, GMEB-1 forms a heterodimer with GMEB-2 (Glucocorticoid modulatory element-binding protein 2) and, once associated with GMEB-2, plays a key role in parvovirus DNA replication. In addition, GMEB-1 functions alone as a trans-acting factor that, by binding to glucocorticoid modulatory elements (GMEs) in TAT (tyrosine aminotransferase) promoters, increases intracellular sensitivity to glucocorticoid concentrations. GMEB-1 also interacts with initiator procaspases and, via this interaction, can inhibit caspase-induced apoptosis. Due to alternative splicing events, GMEB-1 is expressed as two isoforms.

Gen-ID: 10691