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GATA6 is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. Zusätzlich bieten wir Ihnen GATA6 Antikörper (129) und GATA6 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Results show that GATA6 protein levels are reduced in tissue samples from colon cancer patients with miR (zeige MLXIP Proteine)-196b upregulation and that GATA6 is a direct target of miR (zeige MLXIP Proteine)-196b.
Our data suggested that miR-124 decreases GATA6 expression by targeting its 3'-UTR, which in turn inhibits cholangiocarcinoma invasion and metastasis.
Gain-of-function mutations in GATA6 in both a family with early-onset Atrial Fibrillation and Atrioventricular Septal Defects was found.
analysis of the TNF (zeige TNF Proteine)-insulin (zeige INS Proteine) signaling with GATA6 reveals specific patterns of gene expression in cells receiving multiple stimuli
These data show that GATA6 plays a critical role in endoderm and pancreas specification and beta-like cell functionality in humans.
GATA6 variant frequency in sporadic CTDs patients was higher than that in other congenital heart diseases.
Knockdown of GATA6 completely eliminated the effect of TCF1 (zeige HNF1A Proteine), while forced expression of GATA6 induced hESC differentiation
In human Pancreatic Ductal Adenocarcinoma cells, GATA6 inhibits de-differentiation and epithelial-mesenchymal transition both directly and indirectly, through mechanism that involves the regulation of transcription factors, including FOXA1 (zeige FOXA1 Proteine)/2.Loss of GATA6 in PDAC primary samples is associated with altered differentiation and shorter overall patient survival.
GATA6 induces expression of genes essential for growth of colon cancer cells under adherent conditions (REG4 (zeige REG4 Proteine)) and genes required for their clonogenicity (LGR5 (zeige LGR5 Proteine)), and miR (zeige MLXIP Proteine)-363-GATA6-REG4 (zeige REG4 Proteine)/LGR5 (zeige LGR5 Proteine) signaling cascade promotes tumorigenicity of colon cancer cells.
In the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways.
these findings indicated that the downregulation of GATA-6 effectively inhibited airway inflammation and reversed airway remodeling via Cav-1 (zeige CAV1 Proteine)
During wound healing differentiated Gata6(+) cells migrate from the sebaceous duct into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long-term self-renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue.
The authors find that Gata6 protects against DNA damage associated with proliferation, thus preventing cell cycle arrest and apoptosis.
Findings indicate that the Gata6 promoter is activated by Esrrb in association with Ncoa3 (zeige NCOA3 Proteine), and Dax1 (zeige NR0B1 Proteine) inhibited activities of Esrrb and Ncoa3 (zeige NCOA3 Proteine), resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.
GATA4 (zeige GATA4 Proteine) and GATA6 are essential for female fertility, whereas targeting either factor alone causes subfertility. GATA4 (zeige GATA4 Proteine) and GATA6 are also required for the expression of the receptors for prolactin (zeige PRL Proteine) and luteinizing hormone.
GATA4 (zeige GATA4 Proteine)/6-mediated inhibition of hedgehog (zeige SHH Proteine) signaling is a major mechanism regulating pancreatic endoderm specification during patterning of the gut (zeige GUSB Proteine) tube
The role of GATA4 (zeige GATA4 Proteine) in the regulation of cardiomyocyte maturation in the newborn heart and in maintaining diastolic function in the adult heart.
Our results, for the first time, portray a pivotal role of GATA6 in regulating metastatic behaviors of breast cancer cells
data indicated that GATA-6 and Akt2 (zeige AKT2 Proteine) are involved in the mTORC1-mediated regulation of VSMC proliferation and differentiation.
Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.
Results describe the expression of GATA4 (zeige GATA4 Proteine) and 6 during gastrulation and their function in migratory behaviour.
several transcription factors, that is SRF, myocardin, and GATA6, that induce the expression of SM-MHC in animal cap cells
these data suggest an essential role for Pak1 (zeige PAK1 Proteine) as an Erk (zeige MAPK1 Proteine) activator, and Gata6 as an Erk (zeige MAPK1 Proteine) target, during neural crest development.
specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT (zeige WNT2 Proteine) signaling and expand the number of cardiac progenitors.
in zebrafish the gata6 genes are redundant for specification of cardiomyocytes.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
investigation of genes regulated by GATA6, GATA4 (zeige GATA4 Proteine), and both in combination: studies in granulosa cells primed for luteinization
The altered ratio of GATA4 (zeige GATA4 Proteine) to GATA6 after ovulation may allow GATA6 to enhance STAR mRNA accumulation.
GATA4 (zeige GATA4 Proteine) and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1 (zeige NR5A1 Proteine), NR5A2 (zeige NR5A2 Proteine), and the other steroidogenic markers.
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.
GATA-binding factor 6
, transcription factor GATA-6
, GATA-binding protein 6
, DNA-binding protein GATA-GT2
, zinc-finger transcription factor Gata6
, GATA-6 transcription factor
, GATA-binding factor 6-B
, transcription factor xGATA-6B
, GATA binding protein 6
, transcription factor GATA-6-like
, LOW QUALITY PROTEIN: transcription factor GATA-6
, transcription factor GATA6