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GATA6 is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. Zusätzlich bieten wir Ihnen GATA6 Antikörper (124) und GATA6 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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High GATA6 expression is associated with Gastric Cancer.
Increased GATA6 expression is associated with laryngeal squamous cell carcinoma.
These findings suggest that GATA6 might interact with HNF4alpha (zeige HNF4A Proteine) and contribute to the development of mucinous-type lung adenocarcinomas
Genetic variants in GATA6 gene had severe pancreatic atrophy but with abundant beta cells and severe amyloidosis similar to type 2 diabetes.
Study firstly associates GATA6 loss-of-function mutation with increased susceptibility to familial congenital bicuspid aortic valve (BAV) in humans, which provides novel insight into the molecular pathogenesis underlying BAV.
although relatively infrequent in patients with hypertrophic cardiomyopathy, GATA2 (zeige GATA2 Proteine), 4 and 6 transcription factors may represent a novel insight into the molecular mechanisms related to the pathogenesis of hypertrophic cardiomyopathy
loss of one GATA6 allele affects the differentiation of pancreatic progenitors from the early PDX1 (zeige PDX1 Proteine)+ stage to the more mature PDX1 (zeige PDX1 Proteine)+NKX6.1 (zeige NKX6-1 Proteine)+ stage, leading to impaired formation of glucose-responsive beta-like cells; in addition to this GATA6 haploinsufficiency, also identified dosage-sensitive requirements for GATA6 and GATA4 (zeige GATA4 Proteine) in the formation of both definitive endoderm and pancreatic progenitor cells
Results show that GATA6 protein levels are reduced in tissue samples from colon cancer patients with miR (zeige MLXIP Proteine)-196b upregulation and that GATA6 is a direct target of miR (zeige MLXIP Proteine)-196b.
Our data suggested that miR-124 decreases GATA6 expression by targeting its 3'-UTR, which in turn inhibits cholangiocarcinoma invasion and metastasis.
Gain-of-function mutations in GATA6 in both a family with early-onset Atrial Fibrillation and Atrioventricular Septal Defects was found.
Gata6 could be utilized as a biomarker to select the best Pluripotent stem cell (PSC) lines to produce PSC-derived cardiomyocytes.
GATA4 (zeige GATA4 Proteine)/6 are key regulators of steroidogenesis and testicular somatic cell survival.
Phosphorylation of GATA6 by Erk1/2 compels exit from pluripotent state, and the phosphorylation propels a GATA6 positive feedback regulatory circuit to compel primitive endoderm differentiation
These findings identify Gata6-directed differentiation of neural crest to vascular smooth muscle cells as an essential mechanism that specifies the aortic tree, and provide a new framework for how mutations in GATA6 lead to congenital heart disorders in humans.
Data (including data from studies in knockout mice and transgenic mice) suggest that pancreatic islets in adult mice deficient in GATA6 activity exhibit decreased insulin (zeige INS Proteine) content and impaired insulin (zeige INS Proteine) secretion. Gata6-deficient mice are apparently normal at birth; as they age they develop glucose intolerance.
results support a model in which Gata6 contributes to repression of Isl1 (zeige ISL1 Proteine) expression in the anterior of nascent hindlimb buds.
these findings indicated that the downregulation of GATA-6 effectively inhibited airway inflammation and reversed airway remodeling via Cav-1 (zeige CAV1 Proteine)
During wound healing differentiated Gata6(+) cells migrate from the sebaceous duct into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long-term self-renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue.
The authors find that Gata6 protects against DNA damage associated with proliferation, thus preventing cell cycle arrest and apoptosis.
Findings indicate that the Gata6 promoter is activated by Esrrb in association with Ncoa3 (zeige NCOA3 Proteine), and Dax1 (zeige NR0B1 Proteine) inhibited activities of Esrrb and Ncoa3 (zeige NCOA3 Proteine), resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.
Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.
Results describe the expression of GATA4 (zeige GATA4 Proteine) and 6 during gastrulation and their function in migratory behaviour.
several transcription factors, that is SRF, myocardin, and GATA6, that induce the expression of SM-MHC in animal cap cells
these data suggest an essential role for Pak1 (zeige PAK1 Proteine) as an Erk (zeige MAPK1 Proteine) activator, and Gata6 as an Erk (zeige MAPK1 Proteine) target, during neural crest development.
specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT (zeige WNT2 Proteine) signaling and expand the number of cardiac progenitors.
in zebrafish the gata6 genes are redundant for specification of cardiomyocytes.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
investigation of genes regulated by GATA6, GATA4 (zeige GATA4 Proteine), and both in combination: studies in granulosa cells primed for luteinization
The altered ratio of GATA4 (zeige GATA4 Proteine) to GATA6 after ovulation may allow GATA6 to enhance STAR mRNA accumulation.
GATA4 (zeige GATA4 Proteine) and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1 (zeige NR5A1 Proteine), NR5A2 (zeige NR5A2 Proteine), and the other steroidogenic markers.
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.
GATA-binding factor 6
, transcription factor GATA-6
, GATA-binding protein 6
, DNA-binding protein GATA-GT2
, zinc-finger transcription factor Gata6
, GATA-6 transcription factor
, GATA-binding factor 6-B
, transcription factor xGATA-6B
, GATA binding protein 6
, transcription factor GATA-6-like
, LOW QUALITY PROTEIN: transcription factor GATA-6
, transcription factor GATA6