GATA Binding Protein 6 Proteine (GATA6)

GATA6 is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. Zusätzlich bieten wir Ihnen GATA6 Antikörper (143) und GATA6 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GATA6 2627 Q92908
GATA6 14465 Q61169
GATA6 29300 P46153
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,067.17
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,265.17
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,688.67
Details

GATA6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu GATA Binding Protein 6 (GATA6) Interaktionspartnern

Human GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. Genetic variants in GATA6 gene had severe pancreatic atrophy but with abundant beta cells and severe amyloidosis similar to type 2 diabetes.

  2. Study firstly associates GATA6 loss-of-function mutation with increased susceptibility to familial congenital bicuspid aortic valve (BAV) in humans, which provides novel insight into the molecular pathogenesis underlying BAV.

  3. although relatively infrequent in patients with hypertrophic cardiomyopathy, GATA2 (zeige GATA2 Proteine), 4 and 6 transcription factors may represent a novel insight into the molecular mechanisms related to the pathogenesis of hypertrophic cardiomyopathy

  4. loss of one GATA6 allele affects the differentiation of pancreatic progenitors from the early PDX1 (zeige PDX1 Proteine)+ stage to the more mature PDX1 (zeige PDX1 Proteine)+NKX6.1 (zeige NKX6-1 Proteine)+ stage, leading to impaired formation of glucose-responsive beta-like cells; in addition to this GATA6 haploinsufficiency, also identified dosage-sensitive requirements for GATA6 and GATA4 (zeige GATA4 Proteine) in the formation of both definitive endoderm and pancreatic progenitor cells

  5. Results show that GATA6 protein levels are reduced in tissue samples from colon cancer patients with miR (zeige MLXIP Proteine)-196b upregulation and that GATA6 is a direct target of miR (zeige MLXIP Proteine)-196b.

  6. Our data suggested that miR-124 decreases GATA6 expression by targeting its 3'-UTR, which in turn inhibits cholangiocarcinoma invasion and metastasis.

  7. Gain-of-function mutations in GATA6 in both a family with early-onset Atrial Fibrillation and Atrioventricular Septal Defects was found.

  8. analysis of the TNF (zeige TNF Proteine)-insulin (zeige INS Proteine) signaling with GATA6 reveals specific patterns of gene expression in cells receiving multiple stimuli

  9. These data show that GATA6 plays a critical role in endoderm and pancreas specification and beta-like cell functionality in humans.

  10. GATA6 variant frequency in sporadic CTDs patients was higher than that in other congenital heart diseases.

Mouse (Murine) GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. Gata6 could be utilized as a biomarker to select the best Pluripotent stem cell (PSC) lines to produce PSC-derived cardiomyocytes.

  2. GATA4 (zeige GATA4 Proteine)/6 are key regulators of steroidogenesis and testicular somatic cell survival.

  3. Phosphorylation of GATA6 by Erk1/2 compels exit from pluripotent state, and the phosphorylation propels a GATA6 positive feedback regulatory circuit to compel primitive endoderm differentiation

  4. These findings identify Gata6-directed differentiation of neural crest to vascular smooth muscle cells as an essential mechanism that specifies the aortic tree, and provide a new framework for how mutations in GATA6 lead to congenital heart disorders in humans.

  5. Data (including data from studies in knockout mice and transgenic mice) suggest that pancreatic islets in adult mice deficient in GATA6 activity exhibit decreased insulin (zeige INS Proteine) content and impaired insulin (zeige INS Proteine) secretion. Gata6-deficient mice are apparently normal at birth; as they age they develop glucose intolerance.

  6. results support a model in which Gata6 contributes to repression of Isl1 (zeige ISL1 Proteine) expression in the anterior of nascent hindlimb buds.

  7. these findings indicated that the downregulation of GATA-6 effectively inhibited airway inflammation and reversed airway remodeling via Cav-1 (zeige CAV1 Proteine)

  8. During wound healing differentiated Gata6(+) cells migrate from the sebaceous duct into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long-term self-renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue.

  9. The authors find that Gata6 protects against DNA damage associated with proliferation, thus preventing cell cycle arrest and apoptosis.

  10. Findings indicate that the Gata6 promoter is activated by Esrrb in association with Ncoa3 (zeige NCOA3 Proteine), and Dax1 (zeige NR0B1 Proteine) inhibited activities of Esrrb and Ncoa3 (zeige NCOA3 Proteine), resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.

Xenopus laevis GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.

  2. Results describe the expression of GATA4 (zeige GATA4 Proteine) and 6 during gastrulation and their function in migratory behaviour.

  3. several transcription factors, that is SRF, myocardin, and GATA6, that induce the expression of SM-MHC in animal cap cells

Zebrafish GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. these data suggest an essential role for Pak1 (zeige PAK1 Proteine) as an Erk (zeige MAPK1 Proteine) activator, and Gata6 as an Erk (zeige MAPK1 Proteine) target, during neural crest development.

  2. specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT (zeige WNT2 Proteine) signaling and expand the number of cardiac progenitors.

  3. in zebrafish the gata6 genes are redundant for specification of cardiomyocytes.

  4. Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.

Pig (Porcine) GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. investigation of genes regulated by GATA6, GATA4 (zeige GATA4 Proteine), and both in combination: studies in granulosa cells primed for luteinization

  2. The altered ratio of GATA4 (zeige GATA4 Proteine) to GATA6 after ovulation may allow GATA6 to enhance STAR mRNA accumulation.

Cow (Bovine) GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. GATA4 (zeige GATA4 Proteine) and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1 (zeige NR5A1 Proteine), NR5A2 (zeige NR5A2 Proteine), and the other steroidogenic markers.

GATA6 Protein Überblick

Protein Überblick

This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.

Genbezeichner und Symbole assoziert mit GATA Binding Protein 6 Proteine (GATA6)

  • GATA binding protein 6 (GATA6)
  • GATA binding protein 6 (Gata6)
  • GATA binding protein 6 (gata6)
  • GATA binding protein 6 L homeolog (gata6.L)
  • AA410133 Protein
  • cb603 Protein
  • GATA-5 Protein
  • gata-6 Protein
  • gata6 Protein
  • gata6a Protein
  • gata6b Protein
  • pnr Protein
  • tGata6 Protein
  • XGATA-6 Protein
  • XGATA6 Protein

Bezeichner auf Proteinebene für GATA Binding Protein 6 Proteine (GATA6)

GATA-binding factor 6 , transcription factor GATA-6 , GATA-binding protein 6 , DNA-binding protein GATA-GT2 , zinc-finger transcription factor Gata6 , GATA-6 transcription factor , GATA-binding factor 6-B , transcription factor xGATA-6B , GATA binding protein 6 , transcription factor GATA-6-like , GATA-6 , LOW QUALITY PROTEIN: transcription factor GATA-6 , transcription factor GATA6

GENE ID SPEZIES
2627 Homo sapiens
14465 Mus musculus
29300 Rattus norvegicus
395062 Xenopus (Silurana) tropicalis
396390 Gallus gallus
399082 Xenopus laevis
490520 Canis lupus familiaris
100228783 Taeniopygia guttata
100434852 Pongo abelii
58076 Danio rerio
397600 Sus scrofa
654400 Bos taurus
100720264 Cavia porcellus
468495 Pan troglodytes
100820751 Ovis aries musimon
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