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Involved in translation termination in response to the termination codons UAA, UAG and UGA. Zusätzlich bieten wir Ihnen GSPT1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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PABP (zeige PABPC1 Antikörper) enhances the productive binding of the eRF1 (zeige ZFP36L1 Antikörper)-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a which itself has an active role in translation termination.
Data found that the N-terminal glycine repeat of eRF3a influences eRF3a-PABP interaction and that eRF3a 12-GGC allele has a decreased binding affinity for PABP.
GAB2 (zeige GAB2 Antikörper), GSPT1, TFDP2 (zeige TFDP2 Antikörper) and ZFPM1 (zeige ZFPM1 Antikörper) are four new susceptibility loci for testicular germ cell tumor.
The survivin and eRF3 complex may function in spindle formation and segregation of chromosomes and cytokinesis.
Overexpression of ID1 (zeige ID1 Antikörper) in two different cell lines induced STMN3 (zeige STMN3 Antikörper) and GSPT1 at the transcriptional level, while depletion of ID1 (zeige ID1 Antikörper) reduced their expression.
The proteolytic cleavage of eRF3a and eRF3b into p-eRF3 leads to release an amino-terminal fragment containing nuclear export signal to allow the relocalization of eRF3 into the nucleus to interact with the p14ARF.
ERF3 is targeted for caspase (zeige CASP3 Antikörper)-mediated proteolytic cleavage and degradation during DNA damage-induced apoptosis.
Our results show that the presence of the longer allele of eRF3a is correlated with threefold increased risk of breast cancer development
A biological role for the overlapping ERF3 PAM2 motifs in the regulation of deadenylase accessibility to PABPC1 (zeige PABPC1 Antikörper) at the 3' end of poly(A).
crystal structures of the MLLE domain from PABPC1 in complex with the two PAM2 regions of eRF3
Rac1-GSPT1 represents a novel signaling axis in astrocytes that accelerates proliferation in response to inflammation, which is one important factor in the development of astrogliosis/glial scar following CNS injury
Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
G1 to S phase transition 2
, eukaryotic peptide chain release factor GTP-binding subunit ERF3A
, G1 to S phase transition 1
, eukaryotic peptide chain release factor GTP-binding subunit ERF3A-like
, G1 to S phase transition protein 1 homolog
, eukaryotic peptide chain release factor subunit 3a
, G1 to phase transition 1
, G1-to-S transition GTP binding protein
, eukaryotic polypeptide chain release factor 3
, guanine nucleotide regulatory protein
, G1 to S phase transition protein 1
, G1-to-S phase transition 1