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FAT1 is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. Zusätzlich bieten wir Ihnen und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal FAT1 Primary Antibody für IHC, IHC (p) - ABIN4310665
Morris, Kaufman, Gong, Ramaswami, Walsh, Turcan, Eng, Kannan, Zou, Peng, Banuchi, Paty, Zeng, Vakiani, Solit, Singh, Ganly, Liau, Cloughesy, Mischel, Mellinghoff, Chan: Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. in Nature genetics 2013
Show all 6 Pubmed References
Human Polyclonal FAT1 Primary Antibody für IHC, IHC (p) - ABIN4310666
Caruso, Herberth, Bartoli, Puppo, Dumonceaux, Zimmermann, Denadai, Lebossé, Roche, Geng, Magdinier, Attarian, Bernard, Maina, Levy, Helmbacher: Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy. in PLoS genetics 2013
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Disruption of MAPK/ERK (zeige MAPK1 Antikörper) pathway by FAT1 contributes the epithelial mesenchymal transformation in esophageal squamous cell carcinomas.
Loss of function mutations in FAT1 and CASP8 (zeige CASP8 Antikörper) prevent cell adhesion and promote cell migration and proliferation in oral squamous cell carcinoma cell lines.
We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1 (zeige GPS1 Antikörper)) and FAT1
FAT1 and mAb198.3 may offer new therapeutic opportunities for CRC (zeige CALR Antikörper).
Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1 (zeige SH3RF1 Antikörper)) protein interact with FAT1 protein.
At the molecular level, under hypoxia the FAT1 depletion-associated reduction in HIF1alpha (zeige HIF1A Antikörper) was due to compromised EGFR (zeige EGFR Antikörper)-Akt (zeige AKT1 Antikörper) signaling as well as increased VHL (zeige VHL Antikörper)-dependent proteasomal degradation of HIF1alpha (zeige HIF1A Antikörper).
Low FAT1 expression was associated with poor prognosis in children with medulloblastoma. Furthermore, FAT1 may act on Wnt (zeige WNT2 Antikörper) signaling pathway to exert its antitumor effect
Recessive mutations in FAT1 cause a distinct renal disease entity in four families with a combination of steroid-resistance nephrotic syndrome, tubular ectasia, haematuria and facultative neurological involvement.
that loss of FAT1 and beta-catenin (zeige CTNNB1 Antikörper) are associated with breast cancer progression, aggressive behavior, and poor prognosis
FAT1 protein acts upstream of Hippo signalling through TAZ (zeige TAZ Antikörper) protein to regulate neuronal differentiation.
studies suggest that Fat1 controls mitochondrial activity to restrain cell growth during the reparative, proliferative state induced by vascular injury. Given recent reports linking Fat1 to cancer, abnormal kidney and muscle development, and neuropsychiatric disease, this Fat1 function may have importance in other settings of altered cell growth and metabolism
Fat1 deletion in podocytes induces abnormal glomerular filtration barrier development leading to podocyte foot process effacement. Fat1 knockdown in renal tubular cells reduces migration, decreases active RAC1/CDC42 (zeige CDC42 Antikörper) and induces defects in lumen formation.
Fat1 interacts with Fat4 (zeige FAT4 Antikörper) to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.
Fat-1 expression suppresses CD4+ T-cell activation and differentiation in spleen, and reduces inflammatory cytokines and eotaxin in bronchoalveolar lavage and lung tissues of mice.
Endogenous synthesis of n-3 PUFA in the fat-1 mouse attains similar kidney n-3 PUFA composition and eicosanoid levels as compared to fish oil feeding.
FAT1 suppression in activated hepatic stellate cells caused a downregulation of NFkappaB activity
Data find that Fat1 and Fat4 (zeige FAT4 Antikörper) cooperate during mouse development to control renal tubular elongation, cochlear extension, cranial neural tube formation and patterning of outer hair cells in the cochlea.
results confirm a necessary role for FAT1 in the modified adhesion junctions of the renal glomerular epithelial cell and reveal hitherto unsuspected roles for FAT1 in CNS development
Fat1 regulates actin cytoskeletal organization at cell peripheries, thereby modulating cell contacts and polarity.
data are compatible with conservation and sub-functionalization of dachsous 1 (zeige DCHS1 Antikörper), Fj, and Fat signaling in higher vertebrates.
these data provide new insights into the mechanisms of the association between FAT1 and porcine cumulus cell apoptosis.
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and\\/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and\\/or alternative promoter usage exist, but they have not been fully described.
FAT tumor suppressor 1
, FAT tumor suppressor homolog 1
, cadherin ME5
, cadherin family member 7
, cadherin-related family member 8
, cadherin-related tumor suppressor homolog
, protein fat homolog
, protocadherin Fat 1
, fat 1 cadherin
, FAT tumor suppressor homolog 1 (Drosophila)
, protocadherin Fat 1-like