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FBXW8 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. Zusätzlich bieten wir Ihnen FBXW8 Antikörper (48) und FBXW8 Kits (12) und viele weitere Produktgruppen zu diesem Protein an.
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FBXW8 and PARK2 (zeige PARK2 Proteine) are sequestrated into insolubility by ATXN2 (zeige ATXN2 Proteine) PolyQ expansions, but only FBXW8 expression is dysregulated
findings will shed light the role to mechanism of miR (zeige MLXIP Proteine)-218 in regulating JEG-3 cells proliferation via miR (zeige MLXIP Proteine)-218/Fbxw8 axis, and miR (zeige MLXIP Proteine)-218 may serve as a novel potential therapeutic target in human choriocarcinoma in the future
CUL7/Fbxw8 ubiquitin ligase-mediated HPK1 (zeige MAP4K1 Proteine) degradation revealed a direct link and novel role of CUL7/Fbxw8 ubiquitin ligase in the MAPK (zeige MAPK1 Proteine) pathway, which plays a critical role in cell proliferation and differentiation.
Dysregulation of Cul7 and Fbxw8 expression might affect trophoblast turnover in intrauterine growth restriction.
Growth factor-stimulated TBC1D3 (zeige TBC1D3 Proteine) ubiquitination and degradation are regulated by its interaction with CUL7-Fbw8.
Fbxw8 plays an essential role in the proliferation of human trophoblast cells, especially JEG-3 cells.
FBXW8 plays an essential role in cancer cell proliferation throug (zeige CCND1 Proteine)h proteolysis of cyclin D1. It may (zeige CDK1 Proteine) present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively.
FBXW8-CUL7 complex plays a significant role in growth control
mTORC2 (zeige CRTC2 Proteine) negatively feeds back to IRS-1 (zeige IRS1 Proteine) via control of Fbw8 stability and localization.
our data support the concept that expanded ATXN2 (zeige ATXN2 Proteine) undergoes progressive insolubility and affects PABPC1 (zeige PABPC1 Proteine) by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8.
Depletion of FBXW8 caused a significant accumulation of cyclin D1 (zeige CCND1 Proteine), as well as sequestration of CDK1 (zeige CDK1 Proteine) in the cytoplasm. This resulted in a severe reduction of cell proliferation.
Cul7 forms a heterodimeric complex with Cul1 (zeige CUL1 Proteine) in a manner dependent on Fbxw8.
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
F-box and WD-40 domain protein 8
, F-box and WD-40 domain-containing protein 8
, F-box only protein 29
, F-box/WD repeat-containing protein 8
, F-box protein FBX29