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Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation.
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data suggest an important role for DUSP13B in protection from external stress during spermatogenesis
identified a gene on chromosome 10q22.2 using alternative ORFs to encode two distinct DSPs: the testis and skeletal muscle-specific TMDP and a novel muscle-restricted DSP(MDSP)
Here, we report the crystal structure of human TMDP at a resolution of 2.4 A. In spite of high sequence similarity with other DSPs (zeige AANAT ELISA Kits), the crystal structure of TMDP shows distinct structural motifs and surface propertie
expression of both MDSP and TMDP proteins was markedly increased at the 3rd week after birth and continued to increase gradually into adulthood, implying that the physiological functions of both DSPs (zeige AANAT ELISA Kits) are specific to the mature/late-developing organs
Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.
dual specificity phosphatase 13
, dual specificity protein phosphatase 13
, branching-enzyme interacting DSP
, branching-enzyme interacting dual-specificity protein phosphatase
, muscle-restricted DSP
, testis- and skeletal-muscle-specific DSP
, Dsp13-like protein
, dual specificity protein phosphatase isoform MDSP
, dual specificity tyrosine phosphatase TS-DSP6
, dual-specificity tyrosine phosphatase TS-DSP6
, testis and skeletal muscle-specific dual specificity phosphatase
, testis- and skeletal muscle-specific DSP
, muscle-restricted dual specificity phosphatase
, muscle-restricted dual specificity phosphatase; testis and skeletal muscle-specific dual specificity phosphatase