anti-DIS3 Mitotic Control Homolog (S. Cerevisiae) (DIS3) Antikörper

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. Zusätzlich bieten wir Ihnen DIS3 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
DIS3 22894 Q9Y2L1
DIS3 72662 Q9CSH3
DIS3 306103  
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Top anti-DIS3 Antikörper auf antikoerper-online.de

Showing 10 out of 47 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-DIS3 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Hela cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB DIS3 Antibody (Center)  western blot analysis in mouse bladder tissue lysates (15ug/lane).This demonstrates the DIS3 antibody detected DIS3 protein (arrow). DIS3 antibody (Center)  immunohistochemistry analysis in formalin fixed and paraffin embedded human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the DIS3 antibody (Center) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Formalin fixed and paraffin embedded human testis carcinoma reacted with DIS3 Antibody  followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of DIS3 Antibody  in mouse bladder tissue lysates (15ug/lane). This demonstrates the DIS3 antibody detected DIS3 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: DIS3 Antibody [NBP1-85209] - Staining of human colon shows moderate nuclear positivity in glandular cells. Western Blot: DIS3 Antibody [NBP1-85209] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (36.67 KDa) . 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$305.71
Details
Schizosaccharomyces pombe Kaninchen Unkonjugiert IF, WB 100 μL Anmelden zum Anzeigen 9 bis 11 Tage
$385.00
Details
Human Maus Unkonjugiert IF, WB Western Blot analysis of DIS3 expression in transfected 293T cell line by DIS3 MaxPab polyclonal antibody.<br><br>Lane 1: KIAA1008 transfected lysate(105.38 KDa).<br>Lane 2: Non-transfected lysate.<br> Immunofluorescence of <u>purified</u> MaxPab antibody to KIAA1008 on HeLa cell. [antibody concentration 10 ug/ml] 50 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert WB Western Blot: DIS3 Antibody [NBP1-57189] - Hela cell lysate, concentration 0.2-1 ug/ml. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
Details

DIS3 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-DIS3 Antikörper

  1. Human Polyclonal DIS3 Primary Antibody für IHC, IHC (p) - ABIN4305253 : Tomecki, Drazkowska, Kucinski, Stodus, Szczesny, Gruchota, Owczarek, Kalisiak, Dziembowski: Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target. in Nucleic acids research 2014 (PubMed)

  2. Schizosaccharomyces pombe Polyclonal DIS3 Primary Antibody für IF, WB - ABIN2451952 : Kinoshita, Goebl, Yanagida: The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control. in Molecular and cellular biology 1991 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal DIS3 Primary Antibody für ELISA, WB - ABIN564954 : Niemelä, Oghabian, Staals, Greco, Pruijn, Frilander: Global analysis of the nuclear processing of transcripts with unspliced U12-type introns by the exosome. in Nucleic acids research 2014 (PubMed)

  4. Human Polyclonal DIS3 Primary Antibody für IF, WB - ABIN524835 : Xie, Li, Vilborg, Lee, Shu, Yartseva, Šestan, Steitz: Mammalian 5'-capped microRNA precursors that generate a single microRNA. in Cell 2013 (PubMed)

Weitere Antikörper gegen DIS3 Interaktionspartner

Human DIS3 Mitotic Control Homolog (S. Cerevisiae) (DIS3) Interaktionspartner

  1. Data indicate the pathological relevance of exosome component 11 protein (DIS3) mutations in plasma cell dyscrasias and suggest that DIS3 may represent a potential tumor suppressor gene in such disorders.

  2. structure and function of DIS3

  3. The study establishes that the ribonuclease DIS3, targeting LIN28B (zeige LIN28B Antikörper), sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation.

  4. seven novel somatic DIS3 single nucleotide variants (SNVs) and defined three hot spot mutations within the RNB domain.

  5. Overexpression of DIS3 and LRCH1 (zeige LRCH1 Antikörper) associated with adenoma to carcinoma progression is linked to the colorectal cancer specific gain of 13q.

  6. Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing. Similar to S. cerevisiae Dis3p, human Dis3p enhanced RCC1 (zeige RCC1 Antikörper)-stimulated nucleotide release from Ran, in a dose-dependent manner, and bound to GTP (zeige AK3 Antikörper)- or GDP-Ran.

  7. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase (zeige PNPT1 Antikörper)-like ring. There appears to be no interaction between human dis3 and other exosome subunits, however.

Mouse (Murine) DIS3 Mitotic Control Homolog (S. Cerevisiae) (DIS3) Interaktionspartner

  1. The study establishes that the ribonuclease DIS3, targeting LIN28B (zeige LIN28B Antikörper), sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation.

DIS3 Antigen-Profil

Protein Überblick

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities (By similarity).

Genbezeichner und Symbole assoziert mit DIS3

  • DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3) Antikörper
  • DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (Dis3) Antikörper
  • 2810028N01Rik Antikörper
  • bA555G22.1 Antikörper
  • DIS3 Antikörper
  • dis3p Antikörper
  • EXOSC11 Antikörper
  • KIAA1008 Antikörper
  • RGD1304646 Antikörper
  • RP11-342J4.3 Antikörper
  • RRP44 Antikörper

Bezeichner auf Proteinebene für DIS3

exosome complex exonuclease RRP44 , DIS3 mitotic control homolog (S. cerevisiae) , 2810028N01Rik , exosome component 11 , mitotic control protein dis3 homolog , protein DIS3 homolog , ribosomal RNA-processing protein 44

GENE ID SPEZIES
100051938 Equus caballus
452595 Pan troglodytes
694048 Macaca mulatta
22894 Homo sapiens
485491 Canis lupus familiaris
767887 Bos taurus
72662 Mus musculus
306103 Rattus norvegicus
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