Cytochrome B5 Reductase 3 Proteine (CYB5R3)

CYB5R3 encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. Zusätzlich bieten wir Ihnen Cytochrome B5 Reductase 3 Antikörper (149) und Cytochrome B5 Reductase 3 Kits (17) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CYB5R3 1727 P00387
CYB5R3 25035 P20070
CYB5R3 109754 Q9DCN2
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Top Cytochrome B5 Reductase 3 Proteine auf antikoerper-online.de

Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human GST tag Cytochrome B5 Reductase 3 (CYB5R3) (AA 1-301), (full length) protein (GST tag) 1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$1,842.50
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$340.00
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,709.67
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,795.83
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,795.83
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Hefe Hund His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,795.83
Details

CYB5R3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine)

Am meisten referenzierte Cytochrome B5 Reductase 3 Proteine

  1. Human CYB5R3 Protein expressed in Wheat germ - ABIN1350883 : Havemeyer, Bittner, Wollers, Mendel, Kunze, Clement: Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme. in The Journal of biological chemistry 2006 (PubMed)

Weitere Proteine zu Cytochrome B5 Reductase 3 (CYB5R3) Interaktionspartnern

Human Cytochrome B5 Reductase 3 (CYB5R3) Interaktionspartner

  1. study indicated that novel homozygous mutation p.Arg192Cys in CYB5R3 gene present in eight cases and the possibility of high prevalence of heterozygous in Indian population causing Type I recessive congenital methemoglobinemia.

  2. Data suggest that cytochrome b5 (CYB5) and cytochrome b5 reductase 3 (CYB5R3) can reduce human cytoglobin (CYGB) and zebrafish cytoglobins at rates up to 250-fold higher than those reported for the known physiological substrates, hemoglobin and myoglobin; the three proteins (CYB5+CYB5R3+CYGB) appear to constitute a metabolon involved in generation of nitric oxide.

  3. CYB5R3 promotes colonization and metastasis formation and is a prognostic marker of disease-free and overall survival in estrogen receptor-negative breast cancer.

  4. Variants in CYB5A and CYB5R3 should be considered in the evaluation of breast cancer risk in African American women.

  5. Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy.

  6. The results unveil a potential mechanism of action by which CYB5R3 deficiency contributes to the pathophysiological underpinnings of neurological disorders in RHM patients.

  7. NADH-CYB5R deficiency causes two forms of recessive congenital methemoglobinemia with cyanosis.

  8. Dapsone-associated methemoglobinemia in a patient with slow NAT2*5B haplotype and impaired cytochrome b5 reductase activity

  9. A comprehensive overview of the study of structure and function of human cytochrome b5 reductase.

  10. Data indicate that mitochondrial amidoxime reducing components 1 and 2 together with the electron transport proteins NADH-cytochrome b5 reductase (CYB5R) and cytochrome b5 (CYB5) catalyze the reduction of N-hydroxylated compounds such as amidoximes.

  11. Population frequency and age of c.806C > T mutation in CYB5R3 gene as cause of recessive congenital methemoglobinemia in Yakutia.

  12. Novel large deletion c.22-1320_633+1224del in the CYB5R3 gene from patients with hereditary methemoglobinemia

  13. CYB5R3 gene of three probands with type I methemoglobinemia and their relatives were sequenced revealing several putative causative mutations; in one subject multiple mutations were present

  14. We conclude that Cytochrome b(5)and cytochrome b(5) reductase catalyze the reduction of arylhydroxylamines in breast tissue.

  15. novel allelic mutation identified at codon 235 is in helix 5; first report of mental retardation because of the novel mutation, along with a second mutation in the NADH-b5R gene in an Indian family with recessive congenital methemoglobinemia Type II

  16. Dia1 is localized to the perinuclear endoplasmic reticulum in an RNA-zipcode-independent manner in fibroblasts.

  17. novel cSNPs associated with significantly altered protein expression and/or hydroxylamine reduction activities, but only minimally impact overall observed phenotypic variability

  18. It was shown that Yakut patients have none of three missence mutations, Arg57Gln, Leu72Pro, and Val105Met, described in case of this disease in the neighboring populations, Chinese and Japanese, inhabiting the territories south of Yakutia

  19. A decrease of the activity of membrane-bound NADH-methemoglobin reductase and a change of physical state of the lipid bilayer of membranes under oxidative stress were found in erythrocytes in vivo and in vitro.

  20. Amino acid substitution results in congsenital methemoglobinemia.

Mouse (Murine) Cytochrome B5 Reductase 3 (CYB5R3) Interaktionspartner

  1. Amino and carboxy terminal fragments of mDia1 form a tetrameric complex composed of two interlocking N+C dimers.

  2. Nucleation is achieved by a mechanism involving APC-B dimerization and recruitment of multiple actin monomers. Further, APC-B nucleation activity is synergistic with its in vivo binding partner, the formin mDia1

  3. an N-terminal domain spanning residues 129-369(DID) is sufficient for auto-inhibition, but alone is not sufficient for RhoA relief of auto-inhibition, suggesting that sequences N-terminal to DID are important to RhoA binding.

  4. Dia1 is required for the formation of the actin coat around endosomes downstream of RhoB, connecting membrane trafficking with the regulation of actin dynamics.

  5. Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation.

Cytochrome B5 Reductase 3 (CYB5R3) Protein Überblick

Protein Überblick

This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias.

Genbezeichner und Symbole assoziert mit CYB5R3

  • cytochrome b5 reductase 3 (CYB5R3)
  • cytochrome b5 reductase 3 (Cyb5r3)
  • cytochrome b5 reductase 3 (cyb5r3)
  • cytochrome b5 reductase 3 L homeolog (cyb5r3.L)
  • NADH-cytochrome b5 reductase (CNM00240)
  • NADH-cytochrome b5 reductase (Tb11.47.0018)
  • NADH-cytochrome b5 reductase (cyb5r1)
  • 0610016L08Rik Protein
  • 2500002N19Rik Protein
  • B5R Protein
  • C85115 Protein
  • CB5R Protein
  • DDBDRAFT_0218707 Protein
  • DDBDRAFT_0266821 Protein
  • DDB_0218707 Protein
  • DDB_0266821 Protein
  • Dia-1 Protein
  • dia1 Protein
  • fc32h03 Protein
  • Nadhcb5 Protein
  • RNNADHCB5 Protein
  • WU:AL591952.1-001 Protein
  • WU:AL591952.1-002 Protein
  • WU:AL591952.1-003 Protein
  • WU:Cyb5r3 Protein
  • wu:fc32h03 Protein
  • zgc:77071 Protein

Bezeichner auf Proteinebene für CYB5R3

NADH-cytochrome b5 reductase 3 , NADH-cytochrome b5 reductase 3 membrane-bound form , NADH-cytochrome b5 reductase 3 soluble form , diaphorase-1 , B5R , Diaphorase (NADH) (cytochrome b-5 reductase) , diaphorase 1 , diaphorase 1 (NADH) , NADH-cytochrome b5 reductase , cytochrome b5 reductase 3

GENE ID SPEZIES
1727 Homo sapiens
418220 Gallus gallus
25035 Rattus norvegicus
109754 Mus musculus
324560 Danio rerio
380169 Xenopus laevis
458883 Pan troglodytes
474479 Canis lupus familiaris
515773 Bos taurus
3255044 Cryptococcus neoformans var. neoformans JEC21
3664333 Trypanosoma brucei brucei strain 927/4 GUTat10.1
8625067 Dictyostelium discoideum AX4
100170571 Xenopus (Silurana) tropicalis
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