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CCNO, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. Zusätzlich bieten wir Ihnen Cyclin O Antikörper (55) und Cyclin O Kits (12) und viele weitere Produktgruppen zu diesem Protein an.
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In air-exposed airway epithelia, induction of factors required for multiciliogenesis, including cyclin O (Ccno) and Multicilin (Mcidas), is AhR dependent, and air exposure induces AhR binding to the Ccno promoter. Submersion and hypoxic conditions impede AhR-dependent Ccno induction.
Ccno-deficient multiciliated cells fail to sufficiently generate deuterosomes, and only reduced numbers of fully functional centrioles that undergo maturation to ciliary basal bodies are formed.
We thus conclude that cyclin O, as an upstream regulator of MPF, plays an important role in oocyte meiotic resumption in mouse oocytes.
Results show uracil-N-glycosylase (UNG) as a new molecular layer that shapes the specificity of activation-induced deaminase (AID)-induced mutations and may provide new insights into the role of AID in cancer development.
Cyclin O activation correlates with apoptosis induction in vivo.
This study presents the crystal structure of the DDB1-DCAF1-HIV-1-Vpr-uracil-DNA glycosylase (cyclin U) complex.
CCNO is mutated more frequently than expected from the rare previous clinical case reports, leads to severe clinical manifestations, and should therefore be considered an important differential diagnosis of mucociliary clearance disorders.
CCNO mutations have a role in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia
This publication corrected the mistaken attribution of uracil DNA glycosylase activity to this gene.
This publication initially attributed 'uracil-DNA glycosylase' activity to this gene and named it UNG2, but a later publication (PubMed ID: 8419333) more correctly identified UNG2/CCNO as a member of the cyclin protein family.
This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes.
, cyclin O
, cyclin U
, cyclin-like uracil-DNA glycosylase
, uracil DNA glycosylase 2
, uracil-DNA glycosylase 2
, cyclin domain containing