Cyclin O Proteine (CCNO)

CCNO, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. Zusätzlich bieten wir Ihnen Cyclin O Antikörper (55) und Cyclin O Kits (12) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte CCNO CCNO 499528  
CCNO 218630 P0C242
CCNO 10309 P22674
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Hefe Bacteroides fragilis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,548.33
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Hefe Streptomyces coelicolor His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,570.33
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Baculovirus infected Insect Cells Human GST tag   50 μg Anmelden zum Anzeigen 10 bis 12 Tage
$624.55
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CCNO Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu Cyclin O (CCNO) Interaktionspartnern

Mouse (Murine) Cyclin O (CCNO) Interaktionspartner

  1. In air-exposed airway epithelia, induction of factors required for multiciliogenesis, including cyclin O (Ccno) and Multicilin (zeige MCIN Proteine) (Mcidas), is AhR (zeige AHR Proteine) dependent, and air exposure induces AhR (zeige AHR Proteine) binding to the Ccno promoter. Submersion and hypoxic conditions impede AhR (zeige AHR Proteine)-dependent Ccno induction.

  2. Ccno-deficient multiciliated cells fail to sufficiently generate deuterosomes, and only reduced numbers of fully functional centrioles that undergo maturation to ciliary basal bodies are formed.

  3. We thus conclude that cyclin O, as an upstream regulator of MPF (zeige MSLN Proteine), plays an important role in oocyte meiotic resumption in mouse oocytes.

  4. Results show uracil-N-glycosylase (UNG (zeige UNG Proteine)) as a new molecular layer that shapes the specificity of activation-induced deaminase (zeige AICDA Proteine) (AID)-induced mutations and may provide new insights into the role of AID in cancer development.

  5. Cyclin O activation correlates with apoptosis induction in vivo.

Human Cyclin O (CCNO) Interaktionspartner

  1. This study presents the crystal structure of the DDB1-DCAF1-HIV-1-Vpr-uracil-DNA glycosylase (zeige UNG Proteine) (cyclin U) complex.

  2. CCNO is mutated more frequently than expected from the rare previous clinical case reports, leads to severe clinical manifestations, and should therefore be considered an important differential diagnosis of mucociliary clearance disorders.

  3. CCNO mutations have a role in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia

  4. This publication corrected the mistaken attribution of uracil DNA glycosylase (zeige UNG Proteine) activity to this gene.

  5. This publication initially attributed 'uracil-DNA glycosylase (zeige UNG Proteine)' activity to this gene and named it UNG2, but a later publication (PubMed ID: 8419333) more correctly identified UNG2/CCNO as a member of the cyclin (zeige PCNA Proteine) protein family.

Cyclin O (CCNO) Protein Überblick

Protein Überblick

This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes.

Genbezeichner und Symbole assoziert mit Cyclin O Proteine (CCNO)

  • cyclin O (Ccno)
  • cyclin O (ccno)
  • cyclin O (CCNO)
  • cyclin O L homeolog (ccno.L)
  • C86987 Protein
  • Ccnu Protein
  • E130318K11 Protein
  • MGC131111 Protein
  • RGD1565217 Protein
  • UDG2 Protein
  • Ung2 Protein

Bezeichner auf Proteinebene für Cyclin O Proteine (CCNO)

cyclin-O , cyclin O , cyclin U , UDG2 , cyclin-like uracil-DNA glycosylase , uracil DNA glycosylase 2 , uracil-DNA glycosylase 2 , cyclin domain containing

GENE ID SPEZIES
499528 Rattus norvegicus
407893 Xenopus (Silurana) tropicalis
461871 Pan troglodytes
487208 Canis lupus familiaris
706193 Macaca mulatta
734946 Xenopus laevis
218630 Mus musculus
10309 Homo sapiens
100725926 Cavia porcellus
101115826 Ovis aries
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