anti-Chromosome 12 Open Reading Frame 5 (C12orf5) Antikörper

C12orf5 is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. Zusätzlich bieten wir Ihnen Chromosome 12 Open Reading Frame 5 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
C12orf5 57103 Q9NQ88
C12orf5 319801 Q8BZA9
C12orf5    
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Top anti-Chromosome 12 Open Reading Frame 5 Antikörper auf antikoerper-online.de

Showing 10 out of 32 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB 50 μg Anmelden zum Anzeigen 12 bis 14 Tage
$593.40
Details
Human Kaninchen Unkonjugiert IHC (p), WB 50 μg Anmelden zum Anzeigen 12 bis 14 Tage
$593.40
Details
Human Maus Unkonjugiert WB Western Blot analysis of C12orf5 expression in transfected 293T cell line by C12orf5 MaxPab polyclonal antibody.<br><br>Lane 1: C12orf5 transfected lysate(29.7 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert WB Western Blot: TIGAR/C12orf5 Antibody  - Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE gel, diluted at 1:2000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry-Paraffin: TIGAR/C12orf5 Antibody  - Staining of human urinary bladder shows moderate nuclear and cytoplasmic positivity in urothelial cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert IHC (p), WB 50 μg Anmelden zum Anzeigen 12 bis 14 Tage
$593.40
Details
Human Kaninchen Unkonjugiert IHC (p), WB 50 μg Anmelden zum Anzeigen 12 bis 14 Tage
$593.40
Details
Human Maus Unkonjugiert IP, WB   0.05 mg Anmelden zum Anzeigen 18 bis 20 Tage
$415.44
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
Details
Schimpanse Kaninchen Unkonjugiert IHC, WB   0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$550.00
Details

C12orf5 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen Chromosome 12 Open Reading Frame 5 Interaktionspartner

Human Chromosome 12 Open Reading Frame 5 (C12orf5) Interaktionspartner

  1. simultaneous mutations at all four acetylation sites completely abolish its ability to regulate metabolic targets, such as TIGAR and SLC7A11 (zeige SLC7A11 Antikörper). Moreover, p53 (zeige TP53 Antikörper)(4KR) is still capable of inducing the p53 (zeige TP53 Antikörper)-Mdm2 (zeige MDM2 Antikörper) feedback loop, but p53 (zeige TP53 Antikörper)-dependent ferroptotic responses are markedly abrogated

  2. High TIGAR expression was an independent predictor of poor survival and high incidence of relapse in adult patients with CN-AML (zeige RUNX1 Antikörper). TIGAR also showed high expression in multiple human leukemia cell lines and knockdown of TIGAR activated glycolysis through PFKFB3 (zeige PFKFB3 Antikörper) upregulation in human leukemia cells.

  3. the upregulation of hsamiR101 in ccRCC was induced by hypoxia. Its expression deceased the protein expression of TIGAR and promoted glycolysis. This regulatory pathway may represent a novel mechanism of carcinogenesis and requires further investigation.

  4. TIGAR expression in breast carcinoma cells promotes metabolic compartmentalization and tumor growth with a mitochondrial metabolic phenotype with lactate and glutamine (zeige GFPT1 Antikörper) catabolism.

  5. we investigate the crosstalk between PFKFB3 (zeige PFKFB3 Antikörper) and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 (zeige PFKFB3 Antikörper) knockdown

  6. The study showed that miR (zeige MLXIP Antikörper)-101 inhibited viability, induced apoptosis, pushed glucose metabolism flux from the pentose phosphate pathway into glycolysis in prostate cancer PC3 (zeige PCSK1 Antikörper) cell line by decreasing NADPH (zeige NQO1 Antikörper) levels by throughly directly binding to 3'-UTR (zeige UTS2R Antikörper) of TIGAR mRNA and repressing TIGAR expression.

  7. This study demonstrated that a high p53 (zeige TP53 Antikörper) expression could be associated with the promotion of glycolysis in gastric cancer via the modulation of TIGAR expression.

  8. TIGAR expression may be used as a bio-marker for detection of colorectal cancer and can be used as a target for developing therapeutics for the treatment of colorectal cancer.

  9. TIGAR knockdown reduced tumor growth rate.

  10. Geranylgeranoic acid induced upregulation of the TIGAR gene, which might inhibit the glycolysis in HuH-7 cells with p53 (zeige TP53 Antikörper) mutation.

Mouse (Murine) Chromosome 12 Open Reading Frame 5 (C12orf5) Interaktionspartner

  1. TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis.

  2. Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury.

  3. Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (zeige TP53 Antikörper) or TAp73 (zeige TP73 Antikörper).

  4. TIGAR protein expression in brain is increased following ischemia reperfusion injury.

  5. Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 (zeige TXN Antikörper) nuclear translocation.

  6. TIGAR protects ischemic brain injury and preserves mitochodrial function.

  7. TIGAR has roles in efficient intestinal regeneration and tumorigenesis

  8. p53 (zeige TP53 Antikörper)/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis.

  9. p53 (zeige TP53 Antikörper) and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 (zeige TP53 Antikörper) and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress.

Chromosome 12 Open Reading Frame 5 (C12orf5) Antigen-Profil

Protein Überblick

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Genbezeichner und Symbole assoziert mit C12orf5

  • TP53 induced glycolysis regulatory phosphatase (TIGAR) Antikörper
  • TP53 induced glycolysis regulatory phosphatase (tigar) Antikörper
  • TP53 induced glycolysis regulatory phosphatase S homeolog (tigar.S) Antikörper
  • Trp53 induced glycolysis repulatory phosphatase (Tigar) Antikörper
  • AA793651 Antikörper
  • AI595337 Antikörper
  • C12orf5 Antikörper
  • C79710 Antikörper
  • C85509 Antikörper
  • FR2BP Antikörper
  • Tigar Antikörper

Bezeichner auf Proteinebene für C12orf5

TP53-induced glycolysis and apoptosis regulator , fructose-2,6-bisphosphatase TIGAR , probable fructose-2,6-bisphosphatase TIGAR , chromosome 12 open reading frame 5 , fructose-2,6-bisphosphate 2-phosphatase , transactivated by NS3TP2 protein

GENE ID SPEZIES
419040 Gallus gallus
100145723 Xenopus (Silurana) tropicalis
100226990 Taeniopygia guttata
57103 Homo sapiens
734566 Xenopus laevis
615392 Bos taurus
319801 Mus musculus
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