anti-Ataxin 3 (ATXN3) Antikörper

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. Zusätzlich bieten wir Ihnen Ataxin 3 Proteine (12) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ATXN3 4287 P54252
ATXN3 110616 Q9CVD2
ATXN3 60331 O35815
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Top anti-Ataxin 3 Antikörper auf antikoerper-online.de

Showing 10 out of 82 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-ATXN3 Antibody Titration:  0.2-1 ug/ml  Positive Control:  293T cell lysate WB Suggested Anti-ATXN3 <br /> Antibody Titration: 0.2-1 µg/mL <br /> Positive Control:.93T cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti- Ataxin 3 Picoband antibody, Western blotting All lanes: Anti Ataxin 3  at 0.5ug/ml Lane 1: Rat Brain Tissue Lysate at 50ug Lane 2: COLO320 Whole Cell Lysate at 40ug Lane 3: HELA Whole Cell Lysate at 40ug Predicted bind size: 42KD Observed bind size: 42KD Anti- Ataxin 3 Picoband antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-Ataxin 3 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert EIA, FACS, IHC (p), WB ATXN3 Antibody (Center) FC analysis of ZR-75-1 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human brain tissue reacted with ATXN3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ICC, IF, WB Immunocytochemistry/Immunofluorescence: Ataxin-3 Antibody [NBP1-32083] - 293T cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Ataxin 3 protein stained by Ataxin 3 antibody diluted at 1:250. Blue: Hoechst 33342 staining. Western Blot: Ataxin-3 Antibody [NBP1-32083] - Ataxin 3 antibody detects Ataxin 3 protein by western blot analysis. 293T mock transfected (-) or transfected with a construct expressing human Ataxin 3. 10 % SDS-PAGE Ataxin 3 antibody dilution: 1:20000 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Kaninchen Unkonjugiert IF, IHC, WB Western blot analysis of extracts of various cell lines, using ATXN3 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of ATXN3 Antibody (Center) (ABIN653191) in MCF-7 cell line lysates (35 µg/lane). ATXN3 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with ATXN3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Kaninchen Unkonjugiert IHC (p) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Maus Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cell lines, using ATXN3 antibody. 100 μL Anmelden zum Anzeigen 13 bis 14 Tage
$357.50
Details

ATXN3 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen Ataxin 3 Interaktionspartner

Human Ataxin 3 (ATXN3) Interaktionspartner

  1. Studied the role of KPNA3 (karyopherin subunit alpha 3 (zeige KPNA3 Antikörper)) in nuclear transport of ataxin-3 in spinocerebellar ataxia type 3.

  2. Low exon skipping efficiencies combined with reduction in important ataxin-3 protein functions suggest that skipping of exon 8 and 9 is not a viable therapeutic option for spinocerebellar ataxia type-3. The modified protein was incapable of binding poly-ubiquitin chains, which may interfere with its normal deubiquitinating function.

  3. Data suggest ATXN3 binds with low-micromolar affinity to both wild-type p97/VCP (zeige vcp Antikörper) and mutants linked to proteostasis deficiency multisystem proteinopathy 1 (MSP1; also called hereditary inclusion body myopathy); stoichiometry of binding is one ATXN3 molecule per p97/VCP (zeige vcp Antikörper) hexamer in presence of ATP; MSP1 mutants of p97/VCP (zeige vcp Antikörper) bind ATXN3 irrespective of nucleotide state. (VCP (zeige vcp Antikörper) = valosin-containing protein (zeige vcp Antikörper)/ATPase (zeige DNAH8 Antikörper); ATXN3 = ataxin-3)

  4. DNA methylation (zeige HELLS Antikörper) levels in the ATXN3 promoter were significantly higher in SCA3/MJD patients

  5. data elucidate the important role of ataxin-3 proteolysis in the pathogenesis of Machado-Joseph disease.

  6. The findings reveal ATXN3 to be a novel deubiquitinase of Chk1 (zeige CHEK1 Antikörper), providing a new mechanism of Chk1 (zeige CHEK1 Antikörper) stabilization in genome integrity maintenance.

  7. Segregation patterns and factors influencing instability of expanded ATXN3 CAG transmissions in Machado-Joseph disease have been analyzed.

  8. Our data reveal a previously unrecognized balance between pathogenic and potentially therapeutic properties of the ataxin-3-Rad23 interaction; they highlight this interaction as critical for the toxicity of the SCA3 protein, and emphasize the importance of considering protein context when pursuing suppressive avenues.

  9. the opposing activities of RNF4 (zeige RNF4 Antikörper) and ataxin-3 consolidate robust MDC1 (zeige MDC1 Antikörper)-dependent signaling and repair ofDNA double-strand break.

  10. we demonstrated that neural differentiation in these iPS (zeige SLC27A4 Antikörper) cells was accompanied by autophagy and that rapamycin promoted autophagy through degradation of mutant ATXN3 proteins in neurally differentiated spinocerebellar ataxia-3 (zeige SCN8A Antikörper) human induced pluripotent stem cells (p < 0.05). In conclusion, patient-derived iPS (zeige SLC27A4 Antikörper) cells are a good model for studying the mechanisms of SCA3 and may provide a tool for drug discovery in vitro.

Mouse (Murine) Ataxin 3 (ATXN3) Interaktionspartner

  1. findings identify a novel molecular link between ATX-3 and p53 (zeige TP53 Antikörper)-mediated cell death and provide an explanation for the direct involvement of p53 (zeige TP53 Antikörper) in SCA3 disease pathogenesis

  2. We show that chronic VPA treatment did not modify the ATXN3 inclusion load and astrogliosis in affected brain regions However, VPA chronic treatment was able to increase GRP78 (zeige HSPA5 Antikörper) protein levels at 30 weeks of age, one of its known neuroprotective effects

  3. work suggests that in Machado-Joseph disease, mutant ataxin-3 drives an abnormal reduction of ataxin-2 (zeige ATXN2 Antikörper) levels, which overactivates poly(A)-binding protein, increases translation of mutant ataxin-3 and other proteins and aggravates Machado-Joseph disease.

  4. SCA3 knockin mice exhibit robust Atxn3 accumulation both in regions known to be affected in human disease; also display altered splicing of the mutant Atxn3 transcript that results in the formation of a previously described alternative ATXN3 transcript

  5. Data support the importance of ATXN3 in neuronal cells and indicate that an expanded polyQ tract leads to a partial loss of the cellular function of ATXN3 that may be relevant to neurodegeneration.

  6. While ataxin-3 may participate in protein quality control pathways, it does not critically regulate the handling of mutant htt (zeige HTT Antikörper) or contribute to major features of disease pathogenesis in Huntington disease (zeige HTT Antikörper).

  7. Results suggest that postnatal nuclear accumulation of mutant ataxin-3 disrupts dendritic differentiation and mGluR-signaling in mouse model spinocerebellar ataxia type 3 Purkinje cells

  8. Lentiviral-based expression of mutant atxn-3 in the mouse cerebellum induces localized neuropathology sufficient to generate a behavioral ataxic phenotype.

  9. Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.

  10. the efficacy of gene silencing in blocking the MJD-associated motor-behavior and neuropathological abnormalities

Ataxin 3 (ATXN3) Antigen-Profil

Protein Überblick

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit anti-Ataxin 3 (ATXN3) Antikörper

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Bezeichner auf Proteinebene für anti-Ataxin 3 (ATXN3) Antikörper

ataxin-3 , ataxin 3 , ataxin-3-like , Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) , Machado-Joseph disease protein 1 , ataxin 3 variant h , ataxin 3 variant m , ataxin 3 variant ref , josephin , olivopontocerebellar ataxia 3 , spinocerebellar ataxia type 3 protein , Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog , machado-Joseph disease protein 1 homolog

GENE ID SPEZIES
394079 Danio rerio
480229 Canis lupus familiaris
549143 Xenopus (Silurana) tropicalis
738729 Pan troglodytes
790880 Bos taurus
100144422 Sus scrofa
100171397 Ovis aries
444085 Xenopus laevis
100393557 Callithrix jacchus
8249057 Micromonas sp. RCC299
9682664 Micromonas pusilla CCMP1545
4287 Homo sapiens
110616 Mus musculus
60331 Rattus norvegicus
378424 Gallus gallus
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