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ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family.
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ASPN D-repeat polymorphism is not associated with an increased Knee Osteoarthritis risk.
Meta-analysis result based on previously published studies demonstrated that the ASPN D13 allele was a protective factor for OA of knee, hip, and hand. For D14 and D15 allele, meta-analysis did not demonstrate statistically significant association.
higher expression of asporin was noticed in CRC (zeige CALR ELISA Kits) tissues and it was correlated with later clinical stage of the patients. Asporin promoted the migration and invasion of the tumor cells partially through an EGFR (zeige EGFR ELISA Kits)/Src (zeige SRC ELISA Kits)/cortactin (zeige CTTN ELISA Kits)- signaling pathway.
ASPN D15 is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks.
we found that asporin can be downregulated by bone morphogenetic protein 4 (zeige BMP4 ELISA Kits) in Hs578T cells and its upregulation may be facilited by serum-free cultivation or by three dimensional growth
Asporin promotes epithelial mesenchymal transformation, invasion, and migration of pancreatic cancer cellss by activating CD44 (zeige CD44 ELISA Kits)-AKT (zeige AKT1 ELISA Kits)/ERK (zeige EPHB2 ELISA Kits)-NF-kappaB (zeige NFKB1 ELISA Kits) pathway in paracrine and autocrine manner.
High ASPN expression in stroma is associated with prostate cancer progression.
To test the associations of ASPN variations with risk of subsequent oncologic outcomes.
Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR (zeige EGFR ELISA Kits) signaling pathway.
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.
Asporin deficiency changes skin glycosaminoglycan composition, and decorin (zeige DCN ELISA Kits) and biglycan (zeige BGN ELISA Kits) content, which may explain the changes in skin mechanical properties.
inhibition of TLR2- and TLR4 (zeige TLR4 ELISA Kits)-induced inflammatory responses and binding abilities to TLR2 and TLR4 (zeige TLR4 ELISA Kits)
positively regulates FGF-2 (zeige FGF2 ELISA Kits) activity through a direct interaction
Findings suggest that asporin is one of the important cartilage matrix proteins that binds to the ECM (zeige MMRN1 ELISA Kits) and TGF-beta1 (zeige TGFB1 ELISA Kits) and thereby modulates interactions between TGF-beta (zeige TGFB1 ELISA Kits) and its signaling receptors.
PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 (zeige BMP2 ELISA Kits) activity to prevent the periodontal ligament from developing non-physiological mineralization
The findings indicate that TGF-beta1 (zeige TGFB1 ELISA Kits) induces ASPN through Smad3 (zeige SMAD3 ELISA Kits) but that this induction is indirect.
Leucine-rich repeat motif 5 (LRR5) of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 (zeige BMP2 ELISA Kits) interaction.
The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.
Mapping of the OGN (zeige OGN ELISA Kits) and ASPN genes and association with growth and carcass traits.
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
asporin (LRR class 1)
, asporin proteoglycan
, periodontal ligament associated protein 1
, small leucine-rich protein 1C
, biglycan-like protein 3
, periodontal ligament-associated protein 1