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The protein encoded by ARAP1 contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. Zusätzlich bieten wir Ihnen ARAP1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal ARAP1 Primary Antibody für IF, IP - ABIN535240
Kiger, Eklund, Younger, OKane: Transgenic inhibitors identify two roles for protein kinase A in Drosophila development. in Genetics 1999
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Human Monoclonal ARAP1 Primary Antibody für ICC, IP - ABIN302078
Símová, Klíma, Cermak, Sourková, Andera: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. in Apoptosis : an international journal on programmed cell death 2008
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Human Polyclonal ARAP1 Primary Antibody für ELISA - ABIN547166
Miura, Jacques, Stauffer, Kubosaki, Zhu, Hirsch, Resau, Zheng, Randazzo: ARAP1: a point of convergence for Arf and Rho signaling. in Molecular cell 2002
Human Polyclonal ARAP1 Primary Antibody für IP, WB - ABIN261138
Hasegawa, Tsujita, Takenawa, Itoh: ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5. in Molecular biology of the cell 2012
competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 could compete with Cbl for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 in the CIN85-mediated EGFR internalizing process.
Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression.
Increased ARAP1 expression might contribute to type 2 diabetes susceptibility at this Genome-wide association studies locus.
Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.
afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1.
Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population.
The proinsulin-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets.
a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1/5 pathway.
Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin release.
ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking
PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells.
ARAP1 acts primarily on Arf6 in vivo.
ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death.
ARAP1 controls the late steps of the endocytic trafficking of the EGF-R
ARAP1 regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation
Data suggest that ARAP1 is recruited to membranes independently of PtdIns(3,4,5)P(3), the subsequent production of which triggers enzymatic activity.
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
centaurin delta 2
, centaurin, delta 2
, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
, arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
, ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1