Synonyms: 2410002L19Rik,ANK repeat and PH domain-containing protein 1,ARAP 1,Arap1,ARAP1,Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domains containing protein 1,Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1,Arf-GAP with Rho-GAP domain,CENT D2,Centaurin delta 2,Centaurin delta2,Centaurin-delta-2,CENTD 2,CENTD2,Cnt d2,Cnt-d2,Cntd2,KIAA0782,MGC176140,mKIAA0782
Background: The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.