anti-Amyloid P Component, serum (APCS) Antikörper

The protein encoded by APCS is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. Zusätzlich bieten wir Ihnen Amyloid P Component, serum Kits (58) und Amyloid P Component, serum Proteine (37) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
APCS 325 P02743
APCS 29339 P23680
APCS 20219 P12246
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Top anti-Amyloid P Component, serum Antikörper auf antikoerper-online.de

Showing 10 out of 143 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Meerschweinchen Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-APCS Antibody Titration:  1.25ug/ml  Positive Control:  Jurkat cell lysate Rabbit Anti-APCS Antibody  Paraffin Embedded Tissue: Human Intestine Cellular Data: Epithelial cells of intestinal villas Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
€220.35
Details
Maus Kaninchen Unkonjugiert IHC (p), ELISA, WB Anti-Serum Amyloid P Picoband antibody,  All lanes: Anti-Serum Amyloid P at 0.5ug/ml WB: Recombinant Mouse Serum Amyloid P Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD Anti-Serum Amyloid P Picoband antibody, IHC(P): Mouse Kidney Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
€247.79
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB APCS antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the APCS antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. APCS Antibody (C-term) western blot analysis in K562 cell line lysates (35µg/lane).This demonstrates the APCS antibody detected the APCS protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
€345.58
Details
Human Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human Serum; Lane2: Human Urine. 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
€293.81
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Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of 293T cells, using APCS antibody. 100 μL Anmelden zum Anzeigen 16 Days
€318.93
Details
Human Kaninchen Unkonjugiert IHC (p), WB APCS Antibody (C-term)  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the APCS antibody detected the APCS protein (arrow). APCS antibody (C-term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the APCS antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
€340.71
Details
Meerschweinchen Kaninchen Unkonjugiert IHC, IHC (p), WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
€436.43
Details
Ratte Kaninchen Unkonjugiert IHC (p), WB Anti-Serum Amyloid P Picoband antibody,  All lanes: Anti- Serum Amyloid P at 0.5ug/ml WB: Recombinant Rat Serum Amyloid P Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD Anti-Serum Amyloid P Picoband antibody,  IHC(P): Rat Liver Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
€247.79
Details
Human Maus Unkonjugiert IF, WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
€449.41
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of 293T cells, using APCS antibody (ABIN5971040) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded rat lung using APCS antibody (ABIN5971040) at dilution of 1/100 (40x lens). 100 μL Anmelden zum Anzeigen 11 bis 16 Tage
€370.79
Details

Am meisten referenzierte anti-Amyloid P Component, serum Antikörper

  1. Mouse (Murine) Polyclonal APCS Primary Antibody für ELISA, WB - ABIN1573937 : Maher, Dargusch, Ehren, Okada, Sharma, Schubert: Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. in PLoS ONE 2011 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal APCS Primary Antibody für IP, ELISA - ABIN532658 : de Haas: New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein. in FEMS immunology and medical microbiology 2000 (PubMed)
    Show all 3 Pubmed References

  3. Guinea Pig Polyclonal APCS Primary Antibody für IHC, WB - ABIN2777091 : Veerhuis, Boshuizen, Morbin, Mazzoleni, Hoozemans, Langedijk, Tagliavini, Langeveld, Eikelenboom: Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q. in Neurobiology of disease 2005 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen Amyloid P Component, serum Interaktionspartner

Human Amyloid P Component, serum (APCS) Interaktionspartner

  1. The findings suggest that the F57I mutation affects the aggregation process of lysozyme resulting in the formation of cytotoxic species and that SAP is able to prevent cell death in the F57I flies by preventing accumulation of toxic F57I structures.

  2. Data suggest that SAP (serum amyloid P-component) interacts with at least 33 proteins/ligands in plasma containing physiological calcium levels; these ligands can be categorized to include apolipoproteins, complement system proteins, coagulation proteins, and components that regulate proteolysis.

  3. Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects.

  4. SNPs in APCS were associated with late age at onset in familial amyloid polyneuropathy.

  5. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics.

  6. Here, it is reported that X-ray analysis of the SAP complex with CPHPC and cadmium ions provides higher resolution detail of the interaction than is observed with calcium ions.

  7. Compared to wildtype C57BL/6 mice, we find that in Apcs-/- "SAP knock-out" mice, bleomycin induces a more persistent inflammatory response and increased fibrosis.

  8. The effects of SAP and Xiapex (Collagenase Clostridium histolyticum) on fibrocytes derived from Dupuytren's disease, was evaluated.

  9. plasma protein serum amyloid P binds to FcgammaRI on monocytes to inhibit fibrocyte differentiation, and binds to FcgammaRIIa on neutrophils to reduce neutrophil adhesion.

  10. In the late phase post-myocardial infarct there is a coordinated decrease in immune response-inflammation proteins, except for SAP which showed an increase related to the specific activation of the classical complement pathway.

  11. 9 different proteins (haptoglobin, transthyretin, apolipoprotein A-1, serum amyloid P component, apolipoprotein E, complement factor H, fibrinogen gamma, thrombin, complement C3) were identified as a potential diagnostic pattern of Parkinson's disease.

  12. Human SAP binds phosphoethanolamine, while rabbits seem to have low levels of SAP that bind to a lesser extent.

  13. These results indicate that SAP functions as a host defense factor, similar to other peptidoglycan recognition proteins and nucleotide-binding oligomerization domain-like receptors.

  14. SAP may act as an effective receptor mimic to limit influenza A virus infection of airway epithelial cells.

  15. Persons who develop non-affective psychoses have lower levels of certain acute phase proteins, including SAP, at the time of birth.

  16. [review] On the basis of structure, serum amyloid P component is a prototype of the short pentraxin family.

  17. SAP has a new role in reducing the toxicity of early amyloidogenic aggregates in transthyretin amiloidosis.

  18. observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation

  19. Low levels of serum amyloid P mark the brains of individuals who escape dementia despite the presence of beta amyloid plaques and tangles in Alzheimer's disease neuropathology.

  20. Studies indicate that pharmaceutical grade serum amyloid P component and C-reactive protein were isolated and purified.

Mouse (Murine) Amyloid P Component, serum (APCS) Interaktionspartner

  1. SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines

  2. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics.

  3. observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation

  4. Bglu3 is confirmed to be a locus affecting diabetes susceptibility, and Apcs is a probable candidate gene.

  5. binding of SAP to ALD-DNA could switch macrophage phenotypic polarization from proinflammatory M2b to anti-inflammatory M2a via PI3K/Akt-ERK signaling activation, thus exerting protective and therapeutic interventions on murine lupus nephritis

  6. SAP has an effect on macrophages in fibrotic lung disease

  7. sFRP4 negatively regulates bone formation without disrupting phosphorus homeostasis.

  8. Serum amyloid P is elevated in the urine and kidneys of mice during anti-glomerular basement membrane disease, as well as in mice with spontaneously arising lupus nephritis.

  9. Binding of mouse and human SAP to immobilized influenza virus was compared. Mouse SAP bound much less avidly than human SAP.mouse SAP apparently plays no significant role during infection of mice with influenza virus.

  10. Targeted pharmacological depletion of serum amyloid P component for treatment of amyloidosis

  11. during murine tuberculosis (TB) SAP levels were increased; purified mouse SAP inhibited the intra-alveolar macrophage M. tuberculosis growth, in vitro; SAP may thus contribute both to the pathogenesis and pulmonary innate immunity in TB

  12. SAP may modulate the inflammatory response to amyloid fibrils in atherosclerosis

  13. These results show a novel and physiologically significant role for SAP for complement-mediated immunity against an important bacterial pathogen, and provide further evidence for the importance of the classical complement pathway for innate immunity.

  14. Cells sensing they are inflicted with mortal injury can turn on molecular programs insuring not only that they die by apoptosis but also that once they are dead their elimination is (facilitated by SAP) swift and efficient.

Amyloid P Component, serum (APCS) Antigen-Profil

Protein Überblick

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

Genbezeichner und Symbole assoziert mit APCS

  • amyloid P component, serum (APCS) Antikörper
  • amyloid P component, serum (Apcs) Antikörper
  • serum amyloid P-component (Apcs) Antikörper
  • amyloid P component, serum protein L homeolog (apcs.L) Antikörper
  • apcs Antikörper
  • FP Antikörper
  • ptx2 Antikörper
  • sap Antikörper
  • SAP(FP) Antikörper

Bezeichner auf Proteinebene für APCS

9.5S alpha-1-glycoprotein , pentaxin-related , serum amyloid P-component , serum amyloid P component , amyloid P component, serum , SAP , pentraxin , C-reactive protein , amyloid P component serum , APCS amyloid P-component serum protein , Serum amyloid P-component , LOW QUALITY PROTEIN: serum amyloid P-component , Female protein , amyloid P component, serum protein L homeolog

GENE ID SPEZIES
325 Homo sapiens
29339 Rattus norvegicus
396921 Sus scrofa
457427 Pan troglodytes
514488 Bos taurus
100126558 Meleagris gallopavo
20219 Mus musculus
100726823 Cavia porcellus
100352593 Oryctolagus cuniculus
102190278 Capra hircus
101114738 Ovis aries musimon
101826113 Mesocricetus auratus
100049775 Xenopus laevis
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