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ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Zusätzlich bieten wir Ihnen Amiloride-Sensitive Cation Channel 2, Neuronal Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Mammalian Monoclonal ACCN2 Primary Antibody für ISt, IHC - ABIN1304544
Lin, Sun, Chen: Genetic exploration of the role of acid-sensing ion channels. in Neuropharmacology 2015
Show all 3 Pubmed References
Mouse (Murine) Polyclonal ACCN2 Primary Antibody für ELISA, WB - ABIN4277576
Hoagland, Sherwood, Lee, Walker, Askwith: Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. in The Journal of biological chemistry 2010
our results suggest that ASIC1a is critical for liver cancer cell proliferation and its deregulation is frequently linked to liver cancer
the data demonstrate a functional link between ASICs and [Ca(2 (zeige CA2 Antikörper)+)]i/RhoA (zeige RHOA Antikörper) pathway, which contributes to the acidity-induced epithelial-mesenchymal transition.
ASIC1 contributes to breast cancer pathogenesis in response to acidic tumor microenvironments
The results show that acid-sensing ion channel 1, acid-sensing ion channel 2 (zeige ACCN1 Antikörper), and acid-sensing ion channel 3 (zeige ACCN3 Antikörper) are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.
Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling and increased drug resistance, suggesting that ASIC1a/Ca(2 (zeige CA2 Antikörper)+)/PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)).
Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.
The C mutated allele for ACCN2 rs685012 polymorphism was more frequent in panic disorder patients. The ACCN2 TT/ADORA2A (zeige ADORA2A Antikörper) CT diplotype were more represented in controls. This suggests a role for ACCN2 rs685012 polymorphism in PD development in Caucasian
analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel
Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The
Putative GABAA (zeige GABRg1 Antikörper) and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.
Asic1 showed heightened mRNA expression, coherent with the repeated cross-fostering paradigm (RCF)-mice's respiratory hypersensitivity to CO2 and altered nociception.
Notch1 (zeige NOTCH1 Antikörper) signaling may be required for ASIC1a-mediated neurite growth and neuronal differentiation in neuroblastoma (zeige ARHGEF16 Antikörper) cells.
The authors observed no preference for sodium at the "GAS belt" in the central constriction. Instead, they identified a band of glutamate (zeige GRIN1 Antikörper) and aspartate side chains at the lower end of the pore that enables preferential sodium conduction.
Asic1a KO mice exhibited prominent deficits in multiple fear-related behaviors.
ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP (zeige PTPN2 Antikörper) Model of Parkinson Disease
The manuscript demonstrates that postsynaptic neurons of the medial nucleus of the trapezoid body at the mouse calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by protons (coreleased with neurotransmitter from acidified synaptic vesicles). These ASIC-1as contribute to the generation of postsynaptic currents and, more relevant, to calcium influx, which could be
nonselective cation channels ( channels consist of at least one alpha-ENaC (zeige SCNN1A Antikörper) and one or more acid-sensing ion channel 1a (ASIC1a) proteins.
ASIC1a is an important mediator of AHR (zeige AHR Antikörper).
Ca(2 (zeige CA2 Antikörper)+) influx through ASIC1 mediates chronic hypoxia and ET-1 (zeige EDN1 Antikörper)-induced NFATc3 (zeige NFATC3 Antikörper) nuclear import and 2) the scaffolding protein PICK1 (zeige PICK1 Antikörper) is necessary for NFATc3 (zeige NFATC3 Antikörper) nuclear import.
This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (zeige GRIN1 Antikörper) (mGlu) receptor-induced increase in action potential firing.
Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.
Cation channel, amiloride-sensitive, neuronal, 2
, acid-sensing ion channel 1
, acid-sensing ion channel 1a protein
, amiloride-sensitive cation channel 2, neuronal
, brain sodium channel 2
, proton gated cation channel ASIC1
, Amiloride-sensitive cation channel 2, neuronal
, acid sensing ion channel
, degenerin 2
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
, acid-sensing (proton-gated) ion channel 1