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ALPI encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Zusätzlich bieten wir Ihnen Intestinal Alkaline Phosphatase Antikörper (281) und Intestinal Alkaline Phosphatase Kits (40) und viele weitere Produktgruppen zu diesem Protein an.
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Expressions of human intestinal alkaline phosphatase and sucrase-isomaltase, which are intestinal differentiation markers, were highly enhanced in Caco-2 cells by menaquinone-4.
Data indicate alkaline phosphatase (AP) as the primary soluble ectonucleotidase in infants undergoing cardiopulmonary bypass and show decreased capacity to clear AMP (zeige APRT Proteine) when AP activity decreases post-bypass.
Intestinal alkaline phosphatase is a major regulator of gut (zeige GUSB Proteine) mucosal permeability and appears to work at least partly through improving tight junction protein (zeige OCLN Proteine) levels and localization.
A High Level of Intestinal Alkaline Phosphatase Is Protective Against Type 2 Diabetes Mellitus Irrespective of Obesity
Review of the role of intestinal alkaline phosphatase in inflammatory diseases. Loss of IAP expression or function is associated with increased intestinal inflammation, dysbiosis, bacterial translocation and subsequently systemic inflammation.
The expression of ALPi and MUC5AC in cocultures of Caco-2 and HT29 cells developed for permeability studies is reported.
Data indicate that histone deacetylase (zeige HDAC1 Proteine) inhibitors (HDACi) induce intestinal alkaline phosphatase (ALPi) in a subset of colon cancer cell lines in a Kruppel-like factor 5 (KLF5 (zeige KLF5 Proteine))-dependent manner.
Report lowered intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease.
we are the first to demonstrate the alteration of protein expression of iAP in the duodenal mucosa of children with newly diagnosed coeliac disease
Mechanism of IAP action appears to be through dephosphorylation of specific bacterial components, including LPS (zeige IRF6 Proteine), CpG DNA, and flagellin (zeige FliC Proteine), and not on live bacteria. IAP likely targets these bacterially derived molecules as gut (zeige GUSB Proteine) mucosal defense factor.
Authors found that Akp3(-/-) mice acquired lipopolysaccharide tolerance during postweaning development, suggesting that Akp3 plays an important role in immune education.
Intestinal alkaline phosphatase prevents metabolic syndrome in mice.
It is concluded that CD36 (zeige CD36 Proteine) exists in its phosphorylated and dephosphorylated states in mouse enterocytes and that pCD36 is a substrate of global intestinal alkaline phosphatase (gIAP).
These data suggest that IAP is a local immunomodulating factor, perhaps regulating LPS-toll-like receptor 4 (zeige TLR4 Proteine) (TLR4 (zeige TLR4 Proteine)) interaction between commensal microflora and intestinal epithelium.
Suggest role for lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.
Results suggest that intestinal alkaline phosphatase participates in a rate-limiting step regulating fat absorption.
forced high-fat chow induced an 18% greater body weight gain, hepatic steatosis, and visceral fat accumulation in female Akp3(-/-) mice but not in female wild-type controls. there is 2X increase of lipid absorption in Akp3(-/-) male mice.
Intestinal alkaline phosphatase activity may have a role in mediating the accelerated fatty acid intake observed in Akp3 knockout mice fed a high-fat diet.
Secondary structure of CIP after reaction with Co2+ in different conditions.
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is upregulated during small intestinal epithelial cell differentiation.
, alkaline phosphomonoesterase
, intestinal alkaline phosphatase
, intestinal-type alkaline phosphatase
, Alkaline phosphatase 1, intestinal, defined by SSR
, intestinal alkaline phosphatase 1
, intestinal alkaline phosphatase I IAP-I
, intestinal-type alkaline phosphatase 1
, alkaline phosphatase 6
, intestinal alkaline phosphatase V
, alkaline phosphatase, intestinal.1
, alkaline phosphatase, intestinal
, intestinal-type alkaline phosphatase-like