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ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Here we report on a special case of a Ph-like acute lymphoblastic leukemia patient who had a variant ATF7IP/PDGFRB fusion. In this case, a variant fusion was created between ATF7IP exon 9 (instead of exon 13) and PDGFRB exon 11, resulting in the loss of 411 nucleotides and 137 amino acids in the ATF7IP/PDGFRB fusion cDNA and its encoded chimeric protein, respectively.
these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 abundance in the nucleus.
results indicate that ATF7IP does not directly modulate SETDB1 catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners.
these results indicate a critical role for MCAF1 in AP-1-dependent Rta activation of BZLF1 transcription.
We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance
The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence.
Genetic variants at ATF7IP and KLK2 contribute to the variance of %fPSA.
Studies identified three new susceptibility loci DMRT1, TERT and ATF7IP associated with testicular germ cell cancer.
mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1
These data suggest that MBD1.MCAF1.SETDB1 complex facilitates the formation of heterochromatic domains, emphasizing the role of MCAF/AM family proteins in epigenetic control, and describe a new family member, MCAF2.
MBD1- and MCAF1-mediated heterochromatin formation involves SUMO modification
the acidic stretch of the SIM of MCAF1 plays an important role in the binding to SUMO-3.
Two evolutionarily conserved domains of MCAF1 directly interact with Sp1 and the general transcriptional apparatus. Selective depletion of MCAF1 or Sp1 down-regulates TERT and TERC genes in cultured cells, which results in decreased telomerase activity.
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009
activating transcription factor 7-interacting protein 1
, activating transcription factor 7 interacting protein
, activating transcription factor 7-interacting protein 1-like
, ATF-interacting protein
, ATF7-interacting protein
, ATFa-associated modulator
, MBD1-containing chromatin associated factor
, MBD1-containing chromatin-associated factor 1
, ATFa-associated Modulator