MCAF1 Antikörper (Middle Region)

Produktnummer ABIN2780013

Der Kaninchen Polyklonal anti-MCAF1 Antikörper (ABIN2780013) detektiert spezifisch MCAF1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus, Schwein und Ratte.

Kurzübersicht für MCAF1 Antikörper (Middle Region) (ABIN2780013)

Target: MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))

Reaktivität: Maus, Schwein, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MCAF1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Atf7ip Antibody - middle region

Sequenz: MSTPEGEKSE KDGKAEEEER VPAEEQPPVR NEFSRRKRSK SEDMDSVESK

Homologie: Mouse: 100%, Pig: 92%, Rat: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against Atf7ip. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Atf7ip

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37246-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu MCAF1

Target: MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))

Andere Bezeichnung: Atf7ip

Hintergrund:

Background Information: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Atf7ip can both act as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Atf7ip is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Atf7ip may have ATPase activity.

Gene Name: activating transcription factor 7 interacting protein

Alternative Symbols: A, AM, Mcaf, Mcaf1, 2610204M12Rik, 5830415B17Rik

Protein Name: Activating transcription factor 7-interacting protein 1

Molekulargewicht: 138kDa

Gen-ID: 54343

NCBI Accession: NP_062299

UniProt: Q7TT18