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anti-Human OGG1 Antikörper:
anti-Rat (Rattus) OGG1 Antikörper:
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Human Polyclonal OGG1 Primary Antibody für ELISA, FACS - ABIN151034
Mambo, Nyaga, Bohr, Evans: Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines. in Cancer research 2002
Show all 84 Pubmed References
Human Polyclonal OGG1 Primary Antibody für ELISA, ICC - ABIN314155
Roseborough, Gao, Chen, Trush, Zhou, Williams, Wei: The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord. in The American journal of pathology 2006
Show all 15 Pubmed References
Human Polyclonal OGG1 Primary Antibody für ELISA, IHC - ABIN314156
Xydas, Kherani, Chang, Klotz, Hay, Mutrie, Moss, Gu, Schulman, Gao, Hu, Wu, Wei, Oz, Wang: beta(2)-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy. in The Journal of pharmacology and experimental therapeutics 2006
Show all 15 Pubmed References
Human Polyclonal OGG1 Primary Antibody für IHC - ABIN966715
Aburatani, Hippo, Ishida, Takashima, Matsuba, Kodama, Takao, Yasui, Yamamoto, Asano: Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. in Cancer research 1997
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Human Polyclonal OGG1 Primary Antibody für IHC - ABIN966716
Rosenquist, Zharkov, Grollman: Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. in Proceedings of the National Academy of Sciences of the United States of America 1997
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Rat (Rattus) Polyclonal OGG1 Primary Antibody für ELISA, WB - ABIN253303
Kovtun, Liu, Bjoras, Klungland, Wilson, McMurray: OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. in Nature 2007
Human Polyclonal OGG1 Primary Antibody für IHC, WB - ABIN5664036
Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015
OGG1 activity might be inhibited during postreplicative mismatch repair.
Results show ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits.
work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish
Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP (zeige ARFRP1 Antikörper) in downstream steps.
Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.
Overexpressed beta-OGG1 has the same role as alpha-OGG1 in protecting bronchial epithelial cells from apoptosis and mitochondrial dysfunction. Additionally, knocking down OGG1 enhanced oxidative damage-induced apoptosis and mitochondrial dysfunction. The antiapoptotic function of beta-OGG1 involved the JNK (zeige MAPK8 Antikörper) signaling pathway.
The rs2304277 variant in the OGG1 glycosidase gene associated to a significant OGG1 transcriptional down regulation independently of the BRCA mutational status and this variant may exert a synergistic effect together with BRCA1 or BRCA2 (zeige BRCA2 Antikörper) mutations in ovarian cancer
OGG1 can initiate BER at positions off the dyad axis and that this activity is facilitated by spontaneous and transient unwrapping of DNA from the histones. Local nuances in the nucleosome environment and histone-DNA interactions can impact glycosylase activity.
8-oxoguanine DNA glycosylase-1 (OGG1) is the essential protein involved in oxidative stress-induced (zeige SQSTM1 Antikörper) DNA demethylation.
The allele combination of CGC from hOGG1, ITGA2 (zeige ITGA2 Antikörper) and XPD (zeige ERCC2 Antikörper) polymorphisms was significantly associated with increased odds of nasopharyngeal carcinoma.
Increased oxidative DNA damage in primary open angle glaucoma may be attributed to decreased expression of DNA repair enzymes, OGG1 and PARP1 (zeige PARP1 Antikörper), of the base excision repair pathway.
Results show that some polymorphic variants in XRCC1 (zeige XRCC1 Antikörper) and OGG1 are associated with increased DNA damage in Alzheimer's Disease.
The excision of the 8-oxoguanine base with DeltaG# = 16.1 kcal/mol (zeige DUOXA1 Antikörper) proceeded via substitution of the C1-N9 N-glycosidic bond with an H-N9 bond where the negative charge on the oxoG base and the positive charge on the ribose were compensated in a concerted manner by NH3+(Lys249) and CO2-(Asp268), respectively.
The interaction of OGG1 and XRCC1 (zeige XRCC1 Antikörper) DNA repair polymorphisms and arsenic exposure enhances telomeric DNA damage.
Polymorphisms of OGG1 and MTHFR (zeige MTHFR Antikörper) genes are associated with ARC (zeige NOL3 Antikörper) susceptibility
OGG1 plays a role in an LSD1 (zeige KDM1A Antikörper)-dependent pathway of LPS (zeige TLR4 Antikörper)-induced macrophage activation in mice.
These findings demonstrate that OGG-1 negatively regulates inflammatory cytokine release by coordinating molecular interaction with the autophagic pathway in hyperoxia-induced lung injury.
These results together, points to a new paradigm about the role of DNA damage and repair by OGG1 in aging and age-associated disease processes.
results implicate hyperglycemia-induced O-GlcNAcylation of Ogg1 in increased mtDNA damage and, therefore, provide a new plausible biochemical mechanism for diabetic cardiomyopathy.
DNA repair protein (zeige ATRIP Antikörper) OGG1 bound to its substrate is coupled to DNA occupancy of NF-kappaB (zeige NFKB1 Antikörper) and functions in epigenetic regulation of gene expression.
OGG1 plays a protective role in atherosclerosis by preventing excessive inflammasome activation.
OGG1 acts as a STAT1 (zeige STAT1 Antikörper) coactivator and has transcriptional activity in the presence of endotoxin
Ogg1 and Mutyh (zeige MUTYH Antikörper) regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.
Data suggest that OGG1 plays a vital role in the protection of DNA bases from oxidative damage induced by radiofrequency electromagnetic radiation.
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
8-oxoguanine DNA glycosylase
, N-glycosylase/DNA lyase
, 8-OXOGUANINE DNA GLYCOSYLASE
, DNA-formamidopyrimidine glycosylase
, 8-oxoguanine-DNA glycosylase 1
, 8-oxoguanine DNA-glycosylase 1
, n-glycosylase/DNA lyase-like
, 8-hydroxyguanine DNA glycosylase
, AP lyase
, DNA-apurinic or apyrimidinic site lyase
, OGG1 type 1f