OGG1 Antikörper (C-Term)

Produktnummer ABIN966715

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch OGG1 in IHC. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 5+ Publikationen zitiert.

Kurzübersicht für OGG1 Antikörper (C-Term) (ABIN966715)

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OGG1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-OGG1 Antikörper

Bindungsspezifität: C-Term

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human OGG1 (N-glycosylase/DNA lyase)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-OGG1 Antikörper (ABIN966715)

Aburatani, Hippo, Ishida, Takashima, Matsuba, Kodama, Takao, Yasui, Yamamoto, Asano: "Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue." in: Cancer research, Vol. 57, Issue 11, pp. 2151-6, (1997) (PubMed).

Rosenquist, Zharkov, Grollman: "Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 14, pp. 7429-34, (1997) (PubMed).

Roldán-Arjona, Wei, Carter, Klungland, Anselmino, Wang, Augustus, Lindahl: "Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 15, pp. 8016-20, (1997) (PubMed).

Kuo, Sklar: "Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers." in: The Journal of experimental medicine, Vol. 186, Issue 9, pp. 1547-56, (1997) (PubMed).

Bjorâs, Luna, Johnsen, Hoff, Haug, Rognes, Seeberg: "Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites." in: The EMBO journal, Vol. 16, Issue 20, pp. 6314-22, (1997) (PubMed).

Details zu OGG1

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Andere Bezeichnung: OGG1

Hintergrund: DNA repair enzyme that incises DNA at 8-oxoG residues. OGG1 (N-glycosylase/DNA lyase) excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-Nmethylformamidopyrimidine (FAPY) from damaged DNA. OGG1 has a beta-lyase activity that nicks DNA 3' to the lesion. Defects in OGG1 are associated with tumor formation.Defects in OGG1 are a cause of renal cell carcinoma OGG1 belongs to the type-1 OGG1 family.
Synonyms: MMH, MUTM, OGH1

Pathways: DNA Reparatur