BCL2 Antikörper (B-Cell CLL/lymphoma 2) (PE)

Details for Product anti-BCL2 Antibody No. ABIN2853587, Anbieter: Anmelden zum Anzeigen
Antigen
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • BCL2, apoptosis regulator
  • B cell leukemia/lymphoma 2
  • B-cell CLL/lymphoma 2a
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • bcl2a
  • BCL-2
Reaktivität
Human, Maus, Ratte (Rattus)
1056
258
213
54
28
22
18
18
5
4
4
3
2
2
2
2
Wirt
Maus
576
546
18
6
2
2
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser BCL2 Antikörper ist konjugiert mit PE
50
50
44
38
35
25
24
16
15
14
14
14
14
14
14
14
13
13
7
7
7
6
6
6
6
6
6
6
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
837
398
387
340
335
323
234
195
171
81
40
15
14
13
12
11
9
4
3
2
1
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Recombinant rat Bcl-2beta
Klon 83-8B
Isotyp IgG1
Spezifität This antibody reacts with Bcl-2.
Kreuzreaktivität (Details) Species reactivity (tested):Human, mouse, rat
Reinigung Protein A agarose
Andere Bezeichnung Bcl-2 (BCL2 Antibody Abstract)
Hintergrund The Bcl-2 related genes can inhibit (Bcl-XL and Mcl-1) or induce (Bax, Bcl-Xs, Bag and Bad) apoptosis in several systems. Bad was identified as a Bcl-2 interacting protein using a yeast two hybrid screening and λ expression cloning. It has homology to Bcl-2 within the Bcl-2 homolog domains 1 and 2 (BH1 and BH2). In mammalian cells, Bad selectively heterodimerizes with Bcl-XL as well as Bcl-2, but not with other Bcl-2 family members (Bax, Bcl-Xs, Mcl-1 and A1). When Bad heterodimerized with Bcl-XL, it displaced Bax from Bcl-XL and promoted cell death.Synonyms: Apoptosis regulator Bcl-2, B-Cell CLL/lymphoma 2, BCL2, Bcl-2 alpha
Gen-ID 24224
NCBI Accession NP_058689
UniProt P49950
Forschungsgebiet Cancer, Apoptosis/Necrosis
Pathways MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer PBS, 0.09 % NaN3, 1 % BSA
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (PE) (ABIN2853587) anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (PE)
Allgemeine Veröffentlichungen Gallatin, Weissman, Butcher: "A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 5-9, 2006 (PubMed).

Tanaka, Yoshimi, Maeyama, Hagimoto, Kuwano, Hara: "Resistance to Fas-mediated apoptosis in human lung fibroblast." in: The European respiratory journal, Vol. 20, Issue 2, pp. 359-68, 2002 (PubMed).

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