PTPN11 Antikörper

Produktnummer ABIN1944921

Produktdetails anti-PTPN11 Antikörper

Target: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPN11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000. WB: 1:500-1:1000. IHC: 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-PTPN11 Antikörper (ABIN1944921)

Adachi, Sekiya, Miyachi, Matsuno, Hinoda, Imai, Yachi: "Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2." in: FEBS letters, Vol. 314, Issue 3, pp. 335-9, (1993) (PubMed).

Freeman, Plutzky, Neel: "Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 23, pp. 11239-43, (1993) (PubMed).

Bastien, Ramachandran, Liu, Adam: "Cloning, expression and mutational analysis of SH-PTP2, human protein-tyrosine phosphatase." in: Biochemical and biophysical research communications, Vol. 196, Issue 1, pp. 124-33, (1993) (PubMed).

Ahmad, Banville, Zhao, Fischer, Shen: "A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 6, pp. 2197-201, (1993) (PubMed).

Vogel, Lammers, Huang, Ullrich: "Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation." in: Science (New York, N.Y.), Vol. 259, Issue 5101, pp. 1611-4, (1993) (PubMed).

Details zu PTPN11

Target: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Andere Bezeichnung: SH-PTP2 (PTPN11 Produkte)

Synonyme: BPTP3 antikoerper, CFC antikoerper, NS1 antikoerper, PTP-1D antikoerper, PTP2C antikoerper, SH-PTP2 antikoerper, SH-PTP3 antikoerper, SHP2 antikoerper, 2700084A17Rik antikoerper, AW536184 antikoerper, PTP1D antikoerper, SAP-2 antikoerper, SHP-2 antikoerper, Shp2 antikoerper, Syp antikoerper, SYP antikoerper, bptp3 antikoerper, cfc antikoerper, ns1 antikoerper, ptp-2 antikoerper, ptp2c antikoerper, ptpn11 antikoerper, ptpn11-a antikoerper, ptpn11-b antikoerper, shp-2 antikoerper, shp2 antikoerper, fa14b09 antikoerper, wu:fa14b09 antikoerper, wu:fi24f03 antikoerper, zgc:55388 antikoerper, zgc:63553 antikoerper, protein tyrosine phosphatase, non-receptor type 11 antikoerper, protein tyrosine phosphatase, non-receptor type 11 S homeolog antikoerper, protein tyrosine phosphatase, non-receptor type 11, a antikoerper, protein tyrosine phosphatase, non-receptor type 11, b antikoerper, PTPN11 antikoerper, Ptpn11 antikoerper, ptpn11.S antikoerper, ptpn11a antikoerper, ptpn11b antikoerper

Substanzklasse: Viral Protein

Hintergrund: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

Molekulargewicht: 68436 Da

Gen-ID: 5781

UniProt: Q06124

Pathways: JAK-STAT Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, Warburg Effekt