Caspase 8 Antikörper (Caspase 8, Apoptosis-Related Cysteine Peptidase) (AA 346-395)

Details for Product anti-CASP8 Antibody No. ABIN1532005, Anbieter: Anmelden zum Anzeigen
Antigen
  • casp8-A
  • xCaspase-8
  • casp8
  • CASP8
  • CASP-8
  • FLICE
  • MACH
  • Mch5
  • ALPS2B
  • CAP4
  • Casp-8
  • MCH5
  • caspase-8
  • zgc:92075
  • caspase 8, apoptosis-related cysteine peptidase
  • death related ced-3/Nedd2-like protein
  • caspase-8
  • caspase 8
  • casp8
  • Dredd
  • CASP8
  • AaeL_AAEL014148
  • LOC100222284
  • Casp8
  • LOC100348477
Epitop
AA 346-395, pTyr380
43
19
18
16
15
12
10
9
9
8
7
6
6
6
6
5
5
5
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
360
121
96
25
21
20
3
2
1
Wirt
Kaninchen
278
115
10
2
Klonalität
Polyklonal
Konjugat
Dieser Caspase 8 Antikörper ist unkonjugiert
18
13
8
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
360
108
92
79
51
36
36
28
14
13
9
8
6
5
2
2
2
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Tyr380.
Isotyp IgG
Spezifität

Caspase 8 (Phospho-Tyr380) Antibody detects endogenous levels of Caspase 8 only when phosphorylated at Tyr380.

PhosphorylationH:Y380

Reinigung The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
Reinheit > 95 %
Andere Bezeichnung Caspase 8 (CASP8 Antibody Abstract)
Hintergrund

Synonyms: Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Caspase-8 precursor, FADD-homologous ICE/CED-3- like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, ICE8, MACH, MCH5, MORT1-associated CED-3 homolog

NCBI Gene Symbol: CASP8

Molekulargewicht 55 kDa
Gen-ID 841
OMIM 211980
UniProt Q14790
Forschungsgebiet Proteolysis / Ubiquitin, Apoptosis/Necrosis
Pathways Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
Applikationshinweise WB: 1:500~1:1000 ELISA: 1:10000
Kommentare

Unigene-Number: Hs.599762 (NCBI Gene Symbol: CASP8)

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Stable at -20°C for at least 1 year.
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) (pTyr380), (AA 346-395) antibody (ABIN1532005) Western blot analysis of extracts from LOVO cells treated with UV 15', using Caspase ...
Produkt verwendet in: Xu, Xu, Zhou, Zhuang, Wang, Boerner, Wu: "Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis." in: The Journal of biological chemistry, Vol. 288, Issue 46, pp. 33263-71, 2013 (PubMed).

Allgemeine Veröffentlichungen Boldin, Goncharov, Goltsev, Wallach: "Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death." in: Cell, Vol. 85, Issue 6, pp. 803-15, 1996 (PubMed).

Muzio, Chinnaiyan, Kischkel, ORourke, Shevchenko, Ni, Scaffidi, Bretz, Zhang, Gentz, Mann, Krammer, Peter, Dixit: "FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex." in: Cell, Vol. 85, Issue 6, pp. 817-27, 1996 (PubMed).

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