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TNF alpha Antikörper
TNF alpha
Reaktivität: Human, Maus, Meerschweinchen, Rhesusaffen
WB, IHC (p), IHC (fro)
Wirt: Maus
Monoclonal
52B83
unconjugated
Produktnummer ABIN1109397
Produktdetails anti-TNF alpha Antikörper
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Target
Alle TNF alpha Antikörper anzeigen
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Reaktivität
Alle Reaktivitäten für TNF alpha Antikörper
Human, Maus, Meerschweinchen, Rhesusaffen
Wirt
Alle Wirte für TNF alpha Antikörper
Maus
Klonalität
Alle Klonalitäten für TNF alpha Antikörper
Monoklonal
Konjugat
Alle Konjugate für TNF alpha Antikörper
Dieser TNF alpha Antikörper ist unkonjugiert
Applikation
Alle Applikationen für TNF alpha Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
Kreuzreaktivität (Details)
Species reactivity (tested):Human, mouse, guinea pig, rhesus monkey
Aufreinigung
Protein G
Klon
52B83
Isotyp
IgG1
Top Product
Discover our top product TNF alpha Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0.1 mg/mL
Buffer
PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store at 2 - 8 °C.
Details zu TNF alpha
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Target
TNF alpha
(Tumor Necrosis Factor alpha (TNF alpha))
Andere Bezeichnung
Tumor Necrosis Factor (TNF-Alpha) (TNF alpha Produkte )
Synonyme
DIF antikoerper, TNF-alpha antikoerper, TNFA antikoerper, TNFSF2 antikoerper, RATTNF antikoerper, Tnfa antikoerper, tnf antikoerper, TNF-a antikoerper, TNFalpha antikoerper, Tnfsf1a antikoerper, TNFa antikoerper, cTNF antikoerper, Tnf-alpha antikoerper, tnfa-like antikoerper, TNF-ALPHA antikoerper, dif antikoerper, tnfa antikoerper, xtnf antikoerper, tnfsf2 antikoerper, tnf-alpha antikoerper, Cachectin antikoerper, tumor necrosis factor antikoerper, tumor necrosis factor b (TNF superfamily, member 2) antikoerper, tumor necrosis factor alpha antikoerper, tumor necrosis factor a (TNF superfamily, member 2) antikoerper, TNF antikoerper, Tnf antikoerper, tnf antikoerper, tnfb antikoerper, tnf-alpha antikoerper, LOC103694380 antikoerper, tnfa antikoerper
Hintergrund
TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways. TNF-alpha was originally described as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Furthermore, TNF-alpha is found to be a central mediator in many inflammatory and immunological processes. It can be induced by various products of micro-organisms and by various cytokines leading to expression of a wide variety of cytokines. The pro-inflammatory properties of TNF-alpha play a central role in several auto-immune diseases such as rheumatoid arthritis and inhibition by neutralizing molecules have been shown to be beneficial in patients.Synonyms: Cachectin, TNF, TNF-a, TNFA, TNFSF2, Tumor necrosis factor ligand superfamily member 2
UniProt
P01375
Pathways
NF-kappaB Signalweg , Apoptose , Caspase Kaskade in der Apoptose , TLR Signalweg , Cellular Response to Molecule of Bacterial Origin , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Positive Regulation of Endopeptidase Activity , Hepatitis C , Protein targeting to Nucleus , Inflammasome
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