IKK alpha Antikörper
Kurzübersicht für IKK alpha Antikörper (ABIN110582)
Target
Alle IKK alpha (CHUK) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Lagerung
- 4 °C
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- IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))
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Andere Bezeichnung
- IKKa (IkB Kinase)
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Hintergrund
- IKKa (I. B kinase-a , or IKK-1) is part of a large protein complex responsible for the inducible phos-phorylation of I. B proteins. The same protein was originally identified as CHUK (conserved helix-loop-helix ubiquitous kinase), a serine/threonine kinase of unknown function. The human IKKa is a 85 kDa peptide that has been shown to activate NF-. B by phos-phorylation of I. B proteins. IKKa interacts with its upstream kinase, NIK, and its downstream substrate, the I. B proteins. Mutations of IKKa in its kinase domain lead to a dominant-negative phenotype that suppresses TNFa and IL-1ß induced NF-. B activaiton.
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Pathways
- PI3K-Akt Signalweg, NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine
Target
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