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anti-Human AIM2 Antikörper:
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Human Polyclonal AIM2 Primary Antibody für IF, WB - ABIN522906
Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. in Nature 2009
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Human Monoclonal AIM2 Primary Antibody für WB - ABIN1882206
Chen, Ou-Yang, Hung, Liu, Wang, Wang, Hou, Hortobagyi, Hung: AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. in Molecular cancer therapeutics 2006
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Human Monoclonal AIM2 Primary Antibody für WB - ABIN1882191
DeYoung, Ray, Su, Anzick, Johnstone, Trapani, Meltzer, Trent: Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. in Oncogene 1997
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Human Monoclonal AIM2 Primary Antibody für ICC, WB - ABIN1169341
Cresswell, Clarke, Jackson, Darcy, Trapani, Johnstone: Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. in Biochemical and biophysical research communications 2004
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Human Polyclonal AIM2 Primary Antibody für ELISA, IHC - ABIN4278860
Choubey, Duan, Dickerson, Ponomareva, Panchanathan, Shen, Srivastava: Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010
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Mouse (Murine) Polyclonal AIM2 Primary Antibody für ELISA, WB - ABIN4252907
Wenzel, Wunderlich, Besch, Poeck, Willms, Schwantes, Kremer, Sutter, Endres, Schmidt, Rothenfusser: Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III. in Journal of immunology (Baltimore, Md. : 1950) 2011
Human Polyclonal AIM2 Primary Antibody für IP, WB - ABIN948806
Adamczak, de Rivero Vaccari, Dale, Brand, Nonner, Bullock, Dahl, Dietrich, Keane: Pyroptotic neuronal cell death mediated by the AIM2 inflammasome. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014
AIM2 contributes to the maintenance of intestinal integrity via Akt (zeige AKT1 Antikörper) and protects against Salmonella mucosal infection.
study identifies the AIM2 inflammasome and cGAS/IFI16 (zeige IFI16 Antikörper)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
Study conclude that functional AIM2 is preferentially expressed in adult human CD27 (zeige CD27 Antikörper)+ B-cells, but is absent in cord blood mononuclear cells.
results suggest that the function of AIM2 is focused on the innate immune response, and AIM2 is a detrimental host factor for influenza-induced lung injury and mortality.
knockdown of AIM2 by small interfering RNA attenuated caspase-1 (zeige CASP1 Antikörper) activation. the results suggest that EBV infection of human monocytes induces caspase-1 (zeige CASP1 Antikörper)-dependent IL-1beta (zeige IL1B Antikörper) production, and that AIM2, acting as an inflammasome, is involved in this response.
These data indicate that human cytomegalovirus pUL83 interacts with human AIM2 in the cytoplasm during the early stages of virus infection. The pUL83/AIM2 interaction deregulates the activation of AIM2 inflammasome.
The findings reveal an age-dependent reduction of AIM2 expression and activation which may explain reduced cytokine responses to the cytosolic DNA mimic poly(dA:dT) in healthy elderly individuals. Reduced AIM2-mediated sensing with age may contribute to increased vulnerability to bacterial or viral infections in the elderly.
The extent of NLRC3 (zeige NLRC3 Antikörper) and AIM2 gene reduction was correlated with cancer progression.
Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.
A significant upregulation of the PYHIN inflammasomes AIM2 and IFI16 (zeige IFI16 Antikörper) in active inflammatory bowel disease versus controls was found.
this study shows that aim2-like receptors are dispensable for the type I interferon (zeige IFNA Antikörper) response to transfected DNA ligands, DNA virus infection, and lentivirus infection
These results show for the first time that AIM2 plays an important anti-inflammatory, yet inflammasome-independent function in cardiomyocytes
These results demonstrate a central role for the AIM2 inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18 (zeige IL18 Antikörper)/IL-22BP (zeige IL22RA2 Antikörper)/IL-22 (zeige IL22 Antikörper) and STAT3 (zeige STAT3 Antikörper) pathway
AIM2 senses radiation-induced DNA damage in the nucleus to mediate inflammasome activation and cell death.
in vitro activation of the AIM2 inflammasome in murine macrophages and dendritic cells leads to reduced activation of the STING pathway, in part through promoting caspase-1 (zeige CASP1 Antikörper)-dependent cell death.
A tissue-specific role for the AIM2 inflammasome as a sensor for endogenous DNA species in the course of a ligand-dependent autoinflammatory condition.
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
absent in melanoma 2
, interferon-inducible protein AIM2-like
, interferon-inducible protein AIM2
, interferon-inducible protein 210
, interferon-inducible protein p210