phosphoprotein Enriched in Astrocytes 15 Proteine (PEA15)

PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Zusätzlich bieten wir Ihnen PEA15 Antikörper (111) und PEA15 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PEA15 8682 Q15121
PEA15 18611 Q62048
Ratte PEA15 PEA15 364052 Q5U318
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Showing 10 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Escherichia coli (E. coli) Human Unkonjugiert Figure annotation denotes ug of protein loaded and % gel used. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
$680.36
Details
Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 4 Days
$385.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
Details
Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
Details
Wheat germ Human GST tag 25 μg Anmelden zum Anzeigen 11 bis 12 Tage
$591.43
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$632.80
Details
Escherichia coli (E. coli) Human Unkonjugiert   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$5,769.50
Details
Human Unkonjugiert   1 mg Anmelden zum Anzeigen 6 Days
$7,816.29
Details

PEA15 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu phosphoprotein Enriched in Astrocytes 15 (PEA15) Interaktionspartnern

Human phosphoprotein Enriched in Astrocytes 15 (PEA15) Interaktionspartner

  1. PP4 (zeige ANXA5 Proteine) regulates breast cancer cell survival and identifies a novel PP4c (zeige PPP4C Proteine)-PEA15 signalling axis in the control of breast cancer cell survival.

  2. PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.

  3. Data suggest the role of the phospholipase C epsilon-Protein kinase D (zeige PRKD1 Proteine)-PEA15 protein-ribosomal S6 kinase (zeige RPS6KB1 Proteine)-IkappaB-NF-kappa B (zeige NFKB1 Proteine) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.

  4. Integrin alpha5beta1 and p53 (zeige TP53 Proteine) convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin (zeige BIRC5 Proteine) in high-grade glioma.

  5. High PED expression is associated with esophageal carcinoma.

  6. The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.

  7. Latent HCMV infection of CD34 (zeige CD34 Proteine) + cells protects cells from FAS (zeige FAS Proteine)-mediated apoptosis through the cellular IL-10 (zeige IL10 Proteine)/PEA-15 pathway.

  8. New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.

  9. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  10. Omi/HtrA2 (zeige HTRA2 Proteine) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (zeige HTRA2 Proteine) pro-apoptotic marker in the various hepatocellular carcinoma cell lines

Mouse (Murine) phosphoprotein Enriched in Astrocytes 15 (PEA15) Interaktionspartner

  1. Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.

  2. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  3. Activated astrocytes are known to clear the Abeta (zeige APP Proteine) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).

  4. Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (zeige PPARG Proteine)) represses transcription of the ped/pea-15 gene.

  5. The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.

  6. PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (zeige PPP1R11 Proteine)-methyladenine rescued TGF-beta1 (zeige TGFB1 Proteine) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (zeige TGFB1 Proteine) effects in muscle.

  7. Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2.

  8. we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (zeige MAPK1 Proteine) pathways under gonadotropin releasing hormone stimulation

  9. PEA-15 regulates T-cell proliferation

  10. PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.

PEA15 Protein Überblick

Protein Überblick

This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Genbezeichner und Symbole assoziert mit PEA15

  • proliferation and apoptosis adaptor protein 15 (PEA15)
  • phosphoprotein enriched in astrocytes 15A (Pea15a)
  • proliferation and apoptosis adaptor protein 15 (Pea15)
  • phosphoprotein enriched in astrocytes 15 (PEA15)
  • proliferation and apoptosis adaptor protein 15 L homeolog (pea15.L)
  • proliferation and apoptosis adaptor protein 15 (pea15)
  • Astrocytic phosphoprotein PEA-15 (pea15)
  • phosphoprotein enriched in astrocytes 15 (pea15)
  • DKFZp459O1410 Protein
  • HMAT1 Protein
  • HUMMAT1H Protein
  • Mat1 Protein
  • MAT1H Protein
  • PEA-15 Protein
  • PEA15 Protein
  • Pea15a Protein
  • PED Protein
  • Pkcs15 Protein

Bezeichner auf Proteinebene für PEA15

15 kDa phosphoprotein enriched in astrocytes , Phosphoprotein enriched in astrocytes, 15kD , astrocytic phosphoprotein PEA-15 , homolog of mouse MAT-1 oncogene , phosphoprotein enriched in diabetes , mammary transforming gene 1 , phosphoprotein enriched in astrocytes 15 , phosphoprotein enriched in astrocytes 15A , Astrocytic phosphoprotein PEA-15

GENE ID SPEZIES
8682 Homo sapiens
18611 Mus musculus
364052 Rattus norvegicus
510586 Bos taurus
610113 Canis lupus familiaris
705026 Macaca mulatta
734852 Xenopus laevis
100145359 Xenopus (Silurana) tropicalis
100152480 Sus scrofa
100174153 Pongo abelii
100286636 Salmo salar
100730336 Cavia porcellus
557745 Danio rerio
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