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PEA15 Protein (AA 1-130)

PEA15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1692149
  • Target Alle PEA15 Proteine anzeigen
    PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 1-130
    Spezies
    • 4
    • 1
    Human
    Quelle
    • 3
    • 1
    • 1
    Escherichia coli (E. coli)
    Verwendungszweck
    Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15
    Sequenz
    GSHMAEYGTL LQDLTNNITL EDLEQLKSAC KEDIPSEKSE EITTGSAWFS FLESHNKLDK DNLSYIEHIF EISRRPDLLT MVVDYRTRVL KISEEDELDT KLTRIPSAKK YKDIIRQPSE EEIIKLAPPP KKA
    Produktmerkmale
    Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ala130) of Human PEA15.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product PEA15 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    4 °C/-20 °C/-80 °C
    Informationen zur Lagerung
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Haltbarkeit
    3 months
  • Target
    PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
    Andere Bezeichnung
    PEA15 (PEA15 Produkte)
    Synonyme
    HMAT1 Protein, HUMMAT1H Protein, MAT1 Protein, MAT1H Protein, PEA-15 Protein, PED Protein, Pea15a Protein, PEA15 Protein, DKFZp459O1410 Protein, proliferation and apoptosis adaptor protein 15 Protein, phosphoprotein enriched in astrocytes 15 Protein, proliferation and apoptosis adaptor protein 15 L homeolog Protein, Astrocytic phosphoprotein PEA-15 Protein, PEA15 Protein, Pea15 Protein, pea15.L Protein, pea15 Protein
    Hintergrund
    Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
    Alternative Names: Astrocytic Phosphoprotein PEA-15, 15 kDa Phosphoprotein Enriched in Astrocytes, Phosphoprotein Enriched in Diabetes, PED, PEA15
    Molekulargewicht
    15.3 kDa
    UniProt
    Q15121
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